Selective Acetogenins and Their Potential as Anticancer Agents

Frontiers in Pharmacology
Nadia J Jacobo-HerreraAlejandro Zentella-Dehesa

Abstract

The Kingdom Plantae has provided several successful drugs for the treatment of different diseases, including cancer, and continues to be a source of new possible therapeutic molecules. For example, the annonaceous acetogenins (AAs) are secondary metabolites found in the Annonaceae family, which are plants employed in traditional medicine for the treatment of cancer and various other diseases. These polyketides are inhibitors of Complex I in the respiratory chain of tumor cells, a process that is closely related to tumor metabolism, cell death, apoptosis, and autophagy. The goal of this review is to update readers on the role of the AAs as antitumor agents using in vitro and in vivo studies to demonstrate their importance in the area of oncology drug discovery. For this purpose, we performed a literature search in the PubMed scientific database using a range of keywords, including acetogenins and cancer, acetogenins antitumor activity, acetogenins and cytotoxicity, and acetogenins mechanism of action, among others. As a result, we found that the AAs are cytotoxic compounds that can induce apoptosis, cell cycle arrest, and autophagy in vitro, in addition to exhibiting tumor growth inhibition in vivo. The functional group related ...Continue Reading

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Citations

Sep 23, 2020·Chemistry & Biodiversity·Vanessa Gisele Pasqualotto SeverinoThiago André Moura Veiga
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alexandra G DuránFrancisco A Macías
Sep 18, 2020·Protein and Peptide Letters·Loganayaki PeriyasamySridhar Muthusami
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emmanoel V CostaDaniel P Bezerra
Jul 6, 2021·Biochimica Et Biophysica Acta. Biomembranes·Matheus Elias RosaLuciano Caseli
Aug 18, 2021·Food Research International·Nayara Macêdo Peixoto AraujoGlaucia Maria Pastore

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Methods Mentioned

BETA
xenografts
xenograft

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