Selective activation of carotid nerve fibers by acetylcholine applied to the cat petrosal ganglion in vitro

Brain Research
Julio AlcayagaP Zapata

Abstract

The petrosal ganglion innervates carotid body chemoreceptors through the carotid (sinus) nerve. These primary sensory neurons are activated by transmitters released from receptor (glomus) cells, acetylcholine (ACh) having been proposed as one of the transmitters involved in this process. Since the perikarya of primary sensory neurons share several properties with peripheral sensory endings, we studied the electrical responses of the carotid nerve and glossopharyngeal branch to ACh locally applied to the cat petrosal ganglion superfused in vitro. Ganglionar applications of AChCl (1 microg-1 mg) generated bursts of action potentials conducted along the carotid nerve, while only a few spikes were exceptionally recorded from the glossopharyngeal branch in response to the largest doses. Carotid nerve responses to ACh were dose-dependent, the higher doses inducing transient desensitization. Application of nicotine to the petrosal ganglion also evoked dose-dependent excitatory responses in the carotid nerve. Responses to ACh were reversibly antagonized by adding hexamethonium to the superfusate, more intense and prolonged block of ACh responses being produced by mecamylamine. Ganglionar applications of gamma-amino butyric acid and ser...Continue Reading

References

Dec 1, 1977·Life Sciences·K Morimoto, M Sato
Jan 1, 1991·Experimental Brain Research·D L Tanelian
Jan 1, 1982·The Japanese Journal of Physiology·K Morimoto, M Sato
Jan 1, 1980·Circulation Research·A M Brown
Mar 1, 1982·The Journal of Physiology·P I Baccaglini, E Cooper
Jul 1, 1980·British Journal of Pharmacology·D S McQueen
Jan 26, 1981·Brain Research·B DingerS Fidone
Jan 1, 1954·Acta Physiologica Scandinavica·S LANDGRENY ZOTTERMAN

❮ Previous
Next ❯

Citations

Apr 26, 2005·Respiratory Physiology & Neurobiology·Robert S FitzgeraldAlex Balbir
Nov 12, 2002·Respiratory Physiology & Neurobiology·Ricardo FernándezPatricio Zapata
May 11, 2010·Respiratory Physiology & Neurobiology·Carolina R SotoJulio Alcayaga
Oct 1, 2008·Respiratory Physiology & Neurobiology·Rodrigo Del RioRodrigo Iturriaga
Jan 20, 2007·Respiratory Physiology & Neurobiology·Rodrigo IturriagaJulio Alcayaga
Feb 6, 2007·Respiratory Physiology & Neurobiology·P Zapata
Dec 23, 2006·Brain Research·Carmen AlcayagaJulio Alcayaga
Dec 2, 2004·Brain Research. Brain Research Reviews·Rodrigo Iturriaga, Julio Alcayaga
Sep 9, 2006·Respiratory Physiology & Neurobiology·E P ReyesP Zapata
Aug 24, 2013·Respiratory Physiology & Neurobiology·Gabriel IceksonJulio Alcayaga
Nov 13, 2014·Frontiers in Physiology·Ana R NunesEmília C Monteiro
Dec 30, 2014·Frontiers in Physiology·Mauricio A RetamalJulio Alcayaga
Oct 18, 2002·Microscopy Research and Technique·Estelle B Gauda
Oct 22, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Viviana ValdésRodrigo Iturriaga
Aug 24, 2000·Journal of Applied Physiology·R IturriagaM Mosqueira
Feb 12, 2021·Physiological Reviews·Rodrigo IturriagaVirend K Somers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.