Selective activation of microglia facilitates synaptic strength

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Anna K ClarkJurgen Sandkühler

Abstract

Synaptic plasticity is thought to be initiated by neurons only, with the prevailing view assigning glial cells mere specify supportive functions for synaptic transmission and plasticity. We now demonstrate that glial cells can control synaptic strength independent of neuronal activity. Here we show that selective activation of microglia in the rat is sufficient to rapidly facilitate synaptic strength between primary afferent C-fibers and lamina I neurons, the first synaptic relay in the nociceptive pathway. Specifically, the activation of the CX3CR1 receptor by fractalkine induces the release of interleukin-1β from microglia, which modulates NMDA signaling in postsynaptic neurons, leading to the release of an eicosanoid messenger, which ultimately enhances presynaptic neurotransmitter release. In contrast to the conventional view, this form of plasticity does not require enhanced neuronal activity to trigger the events leading to synaptic facilitation. Augmentation of synaptic strength in nociceptive pathways represents a cellular model of pain amplification. The present data thus suggest that, under chronic pain states, CX3CR1-mediated activation of microglia drives the facilitation of excitatory synaptic transmission in the d...Continue Reading

Citations

Nov 5, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Andrea C RossettiRaffaella Molteni
Oct 4, 2015·Current Opinion in Pharmacology·Ke Ren, Ronald Dubner
Jun 16, 2015·Epilepsy & Behavior : E&B·Nikolaus J Sucher, Maria C Carles
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·Katherine A SouthamDavid H Small
Aug 2, 2015·Brain, Behavior, and Immunity·Giampaolo MiliorLaura Maggi
Apr 25, 2016·Current Opinion in Neurobiology·Tuan Leng TayMarco Prinz
Jul 31, 2016·Experimental Physiology·Nikita N BurkeTuan Trang
Nov 5, 2016·Science·Ru-Rong JiYu-Qiu Zhang
Nov 20, 2016·The European Journal of Neuroscience·Anna R CartaElaine Del-Bel
Oct 11, 2016·Scientific Reports·Maria Amalia Di CastroCristina Limatola
Apr 23, 2016·The Journal of Physiology·Tuan Leng TayMarie-Ève Tremblay
Dec 23, 2017·Developmental Neurobiology·Elisa M YorkBrian A MacVicar
Feb 21, 2018·Anesthesiology·Ru-Rong JiWilliam Maixner
Feb 23, 2019·PLoS Biology·Lauren A GreenCody J Smith
Mar 30, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Giovanni Freitas GomesCristovam Wanderley Picanço Diniz
Feb 9, 2018·Nature Reviews. Neuroscience·Kazuhide Inoue, Makoto Tsuda
Jun 24, 2017·Molecular Brain·Robert NisticòStephane Peineau
Jul 19, 2017·The Journal of Cell Biology·Yasmine Cantaut-BelarifAlain Bessis
Nov 16, 2019·Scandinavian Journal of Pain·Marzia Malcangio
Aug 9, 2016·Current Opinion in Anaesthesiology·Marc R Suter
May 30, 2019·Molecular Psychiatry·D S AlbrechtM L Loggia
Jun 24, 2020·Journal of Leukocyte Biology·Idy H T HoXiaodong Liu
Jul 22, 2017·Frontiers in Aging Neuroscience·Ana I RamirezJosé M Ramírez
Dec 26, 2019·Pain Reports·Nadia SolimanAndrew S C Rice
Feb 6, 2020·Journal of Neural Transmission·Ekaterina LazdonDan Frenkel
Sep 10, 2020·Frontiers in Neuroanatomy·S Alex MarshallKimberly Nixon
Dec 10, 2016·Science·M T KronschlägerJ Sandkühler
Dec 4, 2019·Biological & Pharmaceutical Bulletin·Makoto Tsuda
Mar 16, 2018·Journal of Neural Transmission·Augusta PisanuAnna R Carta

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