Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

The Journal of Biological Chemistry
H EnslenR J Davis

Abstract

The cellular response to treatment with proinflammatory cytokines or exposure to environmental stress is mediated, in part, by the p38 group of mitogen-activated protein (MAP) kinases. We report the molecular cloning of a novel isoform of p38 MAP kinase, p38 beta 2. This p38 MAP kinase, like p38 alpha, is inhibited by the pyridinyl imidazole drug SB203580. The p38 MAP kinase kinase MKK6 is identified as a common activator of p38 alpha, p38 beta 2, and p38 gamma MAP kinase isoforms, while MKK3 activates only p38 alpha and p38 gamma MAP kinase isoforms. The MKK3 and MKK6 signal transduction pathways are therefore coupled to distinct, but overlapping, groups of p38 MAP kinases.

References

Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·A S ZervosR Brent
Nov 1, 1994·Trends in Biochemical Sciences·R J Davis
Feb 9, 1996·The Journal of Biological Chemistry·J HanR J Ulevitch
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·C LechnerA Ullrich
Jun 7, 1996·The Journal of Biological Chemistry·T MoriguchiM Hagiwara
Oct 1, 1996·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·A J Whitmarsh, R J Davis
Nov 12, 1996·Biochemical and Biophysical Research Communications·Z LiJ Han
Apr 1, 1997·Current Opinion in Cell Biology·M J Robinson, M H Cobb
Mar 28, 1997·The Journal of Biological Chemistry·K ShirakabeE Nishida
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·D YangR A Flavell
May 1, 1997·Molecular and Cellular Biology·A J WhitmarshR J Davis
Mar 3, 1997·The EMBO Journal·M IordanovP Herrlich
Jun 6, 1997·The Journal of Biological Chemistry·J B CrawleyB M Foxwell
Sep 20, 1997·The Journal of Biological Chemistry·X S WangZ Yao

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Citations

Mar 19, 1999·Journal of Cellular Physiology·R G JainP H Pekala
Oct 10, 2001·European Journal of Immunology·T Mulroy, J Sen
Mar 10, 2000·Biochemical and Biophysical Research Communications·T SudoH Osada
Jun 11, 2002·Journal of Molecular and Cellular Cardiology·Koichi Seta, Junichi Sadoshima
Jun 22, 1999·Immunologic Research·J M SlavikB E Bierer
Oct 11, 2005·Apoptosis : an International Journal on Programmed Cell Death·T AbdollahiG Litwack
Mar 9, 2004·Biochemical and Biophysical Research Communications·Atsuya HabiroYutaka Kohgo
Dec 25, 2003·Gene·Gilles BuchwalterBohdan Wasylyk
Sep 17, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Steffen KoerdtTobias Reuther
Nov 5, 2003·Brain Research. Molecular Brain Research·Paola MaroniLuisa Schiaffonati
Sep 5, 2006·Molecular Cell·David R JonesNullin Divecha
Apr 23, 2004·Trends in Molecular Medicine·James M Olson, Andrew R Hallahan
Nov 12, 2002·Mechanisms of Ageing and Development·Ching-Chyuan Hsieh, John Papaconstantinou
Jun 5, 2003·Mechanisms of Ageing and Development·Ching-Chyuan HsiehJohn Papaconstantinou
Jul 6, 2000·Immunopharmacology·J C LeeJ L Adams
May 3, 2003·Pharmacology & Therapeutics·Leonidas C Platanias
Aug 24, 1999·Pharmacology & Therapeutics·J C LeeJ L Adams
Oct 16, 2002·Psychiatry Research·Carmit NadriYuly Bersudsky
Dec 4, 2001·Biology of the Cell·C Ambrosino, A R Nebreda
Dec 4, 2001·Biology of the Cell·H Enslen, R J Davis
Aug 31, 2001·Progress in Neurobiology·C A Grimes, R S Jope
Oct 31, 2003·Experimental Hematology·Betty S PaceStuart D Critz
Jun 29, 2001·International Journal of Radiation Oncology, Biology, Physics·N MaF F Liu
Aug 5, 2000·Free Radical Biology & Medicine·M RincónR A Davis
Sep 16, 2000·Cellular Signalling·P W ConradD Beitner-Johnson
Mar 19, 2002·Cellular Signalling·David J MacEwan

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