PMID: 2110494Mar 19, 1990Paper

Selective alterations of high affinity [3H]forskolin binding sites in Alzheimer's disease: a quantitative autoradiographic study

Brain Research
D DewarJ McCulloch

Abstract

Quantitative autoradiographic analysis of high affinity [3H]forskolin binding sites was carried out in postmortem brains from normal controls and patients dying with Alzheimer's disease. Choline acetyltransferase (ChAT) activity and senile plaque formation were also quantified. [3H]Forskolin binding was markedly reduced in all layers of middle frontal gyrus in the Alzheimer brains and the deficit correlated with the deficit in ChAT activity in this area. In the hippocampal region [3H]forskolin binding was no different in the Alzheimer brains compared to controls, although ChAT activity was significantly reduced. There was an inconsistent reduction in [3H]forskolin binding in all layers of middle temporal gyrus which did not correlate with the cholinergic deficit. Significant senile plaque formation was observed in all 3 brain regions examined and [3H]forskolin binding did not correlate with plaque formation in any brain region. Thus, while all 3 brain regions were affected by the pathological correlates of Alzheimer's disease, [3H]forskolin binding was consistently reduced only in frontal cortex.

References

Dec 29, 1978·Brain Research·T D ReisineS J Enna
Nov 22, 1988·Neuroscience Letters·L T YoungJ J Warsh
Nov 1, 1985·Archives of Neurology·Z S Khachaturian
Jun 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·E K PerryG Blessed
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P F WorleyS H Snyder
Apr 1, 1987·Journal of Neurochemistry·S ShimohamaM Kameyama
Mar 1, 1987·Annals of Neurology·P F WorleyS H Snyder
Mar 1, 1988·Journal of Neurochemistry·C J SmithN J Birdsall
Nov 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·E K PerryA Fairbairn
Nov 1, 1986·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·S B WallerE D London
Dec 30, 1985·Brain Research·D R GehlertJ K Wamsley
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·K B SeamonJ W Daly
Jan 1, 1983·Neurobiology of Aging·C Q MountjoyH M Evans
Aug 1, 1981·Annals of Neurology·R D TerryD S Horoupian

❮ Previous
Next ❯

Citations

Jan 1, 1994·Journal of Neural Transmission. General Section·T ArakiK Kogure
Jan 1, 1992·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·T ArakiY Ishida
Dec 1, 1995·Molecular and Chemical Neuropathology·R E Cashman, P Grammas
Dec 1, 1991·Pharmacology & Therapeutics·J A Court, E K Perry
Jan 1, 1994·Neurobiology of Aging·P GrammasM J Ball
Jun 1, 1993·Progress in Neurobiology·H HaraK Kogure
Jan 1, 1992·Cellular Signalling·C J FowlerC O'Neill
Jul 1, 1991·Journal of Neurochemistry·M McLaughlinJ T Knowler
Jan 1, 1992·Acta Neurologica Scandinavica. Supplementum·C J FowlerR F Cowburn
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·R F CowburnC O'Neill
Apr 1, 1993·Reviews in the Neurosciences·N NishinoC Tanaka
Dec 18, 1995·Brain Research·T ArakiY Itoyama
Apr 30, 1993·Brain Research·C A Stockmeier, Y Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.