Selective and Catalytic Hydrocarboxylation of Enamides and Imines with CO2 to Generate α,α-Disubstituted α-Amino Acids

Angewandte Chemie
Tao JuDa-Gang Yu

Abstract

The first catalytic hydrocarboxylation of enamides and imines with CO2 to generate valuable α,α-disubstituted α-amino acids is reported. Notably, excellent chemo- and regio-selectivity are achieved, significantly different from previous reports on β-carboxylation of enamides, homocoupling or reduction of imines. Moreover, this transition-metal-free procedure exhibits low loading of an inexpensive catalyst, easily available substrates, mild reaction conditions, high efficiency, facile scalability and easy product derivatization, providing great potential for application in organic synthesis, pharmaceutical chemistry, and biochemistry.

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Citations

Apr 9, 2019·Chemistry, an Asian Journal·Tsuyoshi Mita, Yoshihiro Sato
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saiwen LiuJin Zhang
Sep 24, 2020·Organic & Biomolecular Chemistry·Ting-Kai XiongYing Liang
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Aug 26, 2020·Angewandte Chemie·Francisco José Aguilar TroyanoAdrián Gómez-Suárez
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Feb 10, 2021·Journal of the American Chemical Society·Li-Li LiaoDa-Gang Yu
Dec 17, 2020·Accounts of Chemical Research·Karsten Donabauer, Burkhard König
Apr 7, 2021·Organic Letters·Sascha Grotjahn, Burkhard König
Apr 30, 2021·Organic Letters·Hyungwoo HahmSukwon Hong
May 7, 2021·Accounts of Chemical Research·Jian-Heng YeDa-Gang Yu
Apr 2, 2021·Angewandte Chemie·Xiao-Wang ChenDa-Gang Yu
May 19, 2021·Chemical Society Reviews·Megan Amy Bryden, Eli Zysman-Colman
May 20, 2021·Organic & Biomolecular Chemistry·M Victoria BoboAaron K Vannucci
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