Selective and effective bactericidal activity of the cobalt (II) cation against Helicobacter pylori

Helicobacter
Sylvaine F A BruggraberJonathan J Powell

Abstract

Although the anti-Helicobacter pylori activity of bismuth is well established, the therapeutic potential of other metal ions against the organism is not known. We measured the minimum inhibitory concentrations of a series of metal ions, including several cobalt (II) compounds against four type strains and seven clinical isolates of H. pylori using three standard broth culture media and a defined medium. Other intestinal bacteria were also investigated for specificity of action. Cobalt chloride had marked activity against H. pylori (minimum inhibitory concentration range was 0.03-1.0 mg/l). The effect was specific because other transition metals had no effect and other intestinal bacteria were not affected by cobalt chloride. Activity was attributable to free cobalt ions as ligands inhibited activity in proportion to their affinity for the ions. Inhibition of cobalt activity was also observed in the presence of nickel, in a dose dependent fashion. However, cobalt activity was not directed towards the nickel-dependent urease enzyme because its effect was similar in wild-type and urease negative mutant strains of H. pylori. Finally, the viability of H. pylori was reduced at the same rate with 2 mg/l cobalt as with 1 mg/l amoxicill...Continue Reading

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Citations

Jun 15, 2007·Critical Reviews in Food Science and Nutrition·Nils-Gunnar Ilbäck, Göran Friman
Jul 19, 2006·Clinical Microbiology Reviews·Johannes G KustersErnst J Kuipers
Jul 21, 2010·Infection and Immunity·Jeroen StoofArnoud H M van Vliet
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Feb 12, 2021·Metallomics : Integrated Biometal Science·Brittni R KelleyJeremiah G Johnson

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