Selective and independent activation of four motor fascicles using a four contact nerve-cuff electrode

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Matthew D Tarler, J T Mortimer

Abstract

Any one of the four motor nerves in the cat sciatic nerve could be activated selectively and independently, from threshold to saturation, using a self-sizing spiral cuff electrode containing four radially placed monopolar contacts. These studies were carried out in nine adult cats with acute implants. Of the 36 possible fascicles, 23 fascicles could be activated selectively with current stimuli applied to a single contact and ten of the remaining fascicles could be activated selectively with current stimuli applied to two contacts, "field steering." In three experiments, time constraints precluded attempting selective activation through "field steering" techniques. In eight of the ten cases where "field steering" was used, a positive and a negative current source (anodic steering) were required to achieve the desired fascicle and in the remaining two cases, two negative current sources (cathodic steering) were required. The relative distance from the electrode contacts to each fascicle was well correlated to the order in which each fascicle was activated. In seven experiments, carried out in two animals, selective activation was verified by collision block techniques. The results of these experiments support the hypothesis that...Continue Reading

Citations

Aug 21, 2008·Journal of Neural Engineering·Hui LuHillel J Chiel
Nov 11, 2009·Journal of Neural Engineering·K H PolasekD J Tyler
Jan 28, 2010·Journal of Rehabilitation Research and Development·Kenneth J GustafsonRonald J Triolo
Mar 9, 2010·Journal of Neural Engineering·M A SchieferD J Tyler
Jan 10, 2012·Journal of Computational Neuroscience·Matthew A SchieferRonald J Triolo
Sep 26, 2015·Bio-medical Materials and Engineering·Hamed Taghipour-FarshiYaghoub Salekzamani
Mar 20, 2015·Muscle & Nerve·Hyun-Joo Park, Dominique M Durand
Sep 12, 2019·Journal of Neural Engineering·Cynthia K OverstreetEdward W Keefer
Jul 12, 2017·Journal of Neuroengineering and Rehabilitation·Breanne P ChristieRonald J Triolo
May 18, 2006·Journal of Neural Engineering·Daniel K LeventhalDominique M Durand
Mar 9, 2010·Journal of Neural Engineering·E M HudakH B Martin
Jul 12, 2005·Annual Review of Biomedical Engineering·P Hunter Peckham, Jayme S Knutson
Sep 4, 2019·Journal of Neural Engineering·Allison M StillerBryan J Black
Mar 6, 2021·Frontiers in Neuroscience·Matthew T FlavinJongyoon Han
Nov 20, 2019·Journal of Neuroscience Methods·Christopher E Larson, Ellis Meng
Jun 8, 2021·The Annals of Otology, Rhinology, and Laryngology·Ronald SahyouniHarrison W Lin
Jul 25, 2021·Journal of Neuroengineering and Rehabilitation·Kristen GelenitisRonald Triolo
Oct 28, 2021·Journal of Neural Engineering·Smruta KoppakaDustin J Tyler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Matthew D Tarler, J T Mortimer
IEEE Transactions on Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Warren M Grill, J T Mortimer
IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Matthew D Tarler, J T Mortimer
IEEE Transactions on Bio-medical Engineering
C VeraartJ T Mortimer
IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
Katharine H PolasekDustin J Tyler
© 2022 Meta ULC. All rights reserved