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Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate

Biochemical Pharmacology

Mar 29, 1994

Claudia M Jochheim, Thomas A Baillie

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Abstract

Exposure of yeast glutathione reductase (GR) in vitro to S-(N-methylcarbamoyl)glutathione (SMG) and S-(N-methylcarbamoyl)cysteine (SMC), two carbamoylating metabolites of methylisocyanate (MIC), led to a time-dependent, irreversible loss of enzyme activity (50-90%) over a period of 3 hr...read more

Mentioned in this Paper

Cysteine
Enzymes, antithrombotic
Glutathione Reductase
Enzymes, peripheral vasodilators
Antineoplastic Agents
Analogs & derivatives
Glutathione Disulfide
NADP
Analog
Enzymes, hematological
Paper Details
References
  • References18
  • Citations19
12
  • References18
  • Citations19
12

Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate

Biochemical Pharmacology

Mar 29, 1994

Claudia M Jochheim, Thomas A Baillie

PMID: 8161349

DOI: 10.1016/0006-2952(94)90392-1

Abstract

Exposure of yeast glutathione reductase (GR) in vitro to S-(N-methylcarbamoyl)glutathione (SMG) and S-(N-methylcarbamoyl)cysteine (SMC), two carbamoylating metabolites of methylisocyanate (MIC), led to a time-dependent, irreversible loss of enzyme activity (50-90%) over a period of 3 hr...read more

Mentioned in this Paper

Cysteine
Enzymes, antithrombotic
Glutathione Reductase
Enzymes, peripheral vasodilators
Antineoplastic Agents

Related Papers

Paper Details
References
  • References18
  • Citations19
12
  • References18
  • Citations19
12

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