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Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate

Biochemical Pharmacology

Mar 29, 1994

C M Jochheim, T A Baillie

Abstract

Exposure of yeast glutathione reductase (GR) in vitro to S-(N-methylcarbamoyl)glutathione (SMG) and S-(N-methylcarbamoyl)cysteine (SMC), two carbamoylating metabolites of methylisocyanate (MIC), led to a time-dependent, irreversible loss of enzyme activity (50-90%) over a period of 3 hr...read more

Mentioned in this Paper

GPX1 gene
GSR gene
Glutathione Measurement
Metabolic Inhibition
Analogs & derivatives
Analog
Enzyme Activity
NADP
Nitrosourea Compounds
Antineoplastic Agents
5
Paper Details
References
  • References18
  • Citations22
12
  • References18
  • Citations22
123

Selective and irreversible inhibition of glutathione reductase in vitro by carbamate thioester conjugates of methyl isocyanate

Biochemical Pharmacology

Mar 29, 1994

C M Jochheim, T A Baillie

PMID: 8161349

DOI: 10.1016/0006-2952(94)90392-1

Abstract

Exposure of yeast glutathione reductase (GR) in vitro to S-(N-methylcarbamoyl)glutathione (SMG) and S-(N-methylcarbamoyl)cysteine (SMC), two carbamoylating metabolites of methylisocyanate (MIC), led to a time-dependent, irreversible loss of enzyme activity (50-90%) over a period of 3 hr...read more

Mentioned in this Paper

GPX1 gene
GSR gene
Glutathione Measurement
Metabolic Inhibition
Analogs & derivatives
Analog
Enzyme Activity
NADP
Nitrosourea Compounds
Antineoplastic Agents
5

Related Papers

Paper Details
References
  • References18
  • Citations22
12
  • References18
  • Citations22
123
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