Selective and non-selective non-steroidal anti-inflammatory drugs differentially regulate pulmonary vein and atrial arrhythmogenesis

International Journal of Cardiology
Chien-Jung ChangYi-Jen Chen

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of atrial fibrillation (AF). This study investigated whether selective and non-selective NSAIDs differentially regulate the arrhythmogenesis of pulmonary veins and atria. Conventional microelectrodes were used to record action potentials (APs) in isolated rabbit PVs, sinoatrial node (SAN), left atrium (LA), and right atrium (RA) preparations before and after celecoxib or indomethacin administration. A whole-cell patch clamp was used to record the sodium-calcium exchanger (NCX) current, L-type calcium current (ICa-L), and late sodium current (INa-late) before and after celecoxib administration in isolated PV cardiomyocytes. Celecoxib (0.3, 1, and 3 μM) reduced PV spontaneous beating rates, and induced delayed afterdepolarizations and burst firings in four of eight PV preparations (50%, p<0.05). Celecoxib also reduced SAN beating rates and decreased AP durations (APDs) in RA and LA, but did not change the resting membrane potential. Indomethacin (0.3, 1, 3, and 10 μM) changed neither the PV or SAN beating rates nor RA APDs, but it reduced LA APDs. Celecoxib (3 μM) significantly increased the NCX current and decreased the ICa-L, but did not change the INa-late. Ranol...Continue Reading

References

Aug 1, 1976·Annals of the Rheumatic Diseases·H W EmoriC Pearson
Aug 1, 1991·Stroke; a Journal of Cerebral Circulation·P A WolfW B Kannel
Dec 3, 2004·The New England Journal of Medicine·William G Stevenson, Lynne W Stevenson
Jul 1, 2005·The Journal of Biological Chemistry·Ken-Ichiro TanakaTohru Mizushima
Feb 25, 2006·European Heart Journal·Demosthenes G Katritsis
Jun 21, 2006·Journal of Cardiovascular Pharmacology·Raymond C Harris
Jul 25, 2007·Cardiovascular Toxicology·Brian B HasinoffXing Wu
Apr 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Dairong WangGarret A FitzGerald
Sep 29, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Nabil FoudiMagnus Bäck
Mar 13, 2010·Expert Review of Cardiovascular Therapy·Thorsten Reffelmann, Robert A Kloner
Jun 10, 2010·Circulation·Yiqun HuiGarret A FitzGerald
Sep 15, 2010·Archives of Internal Medicine·Raffaele De CaterinaLuís Alberto García Rodríguez
Mar 23, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles AntzelevitchLuiz Belardinelli
Aug 4, 2011·Expert Review of Cardiovascular Therapy·Juan TamargoEva Delpón
Nov 3, 2012·Circulation. Arrhythmia and Electrophysiology·Chien-Jung ChangYi-Jen Chen
Mar 19, 2013·Journal of Biomedical Science·Chien-Jung ChangYi-Jen Chen
Mar 19, 2014·European Journal of Pharmacology·Roman V Frolov, Satpal Singh
Jul 25, 2014·Pediatric Rheumatology Online Journal·Rachel E SobelUNKNOWN Pediatric Rheumatology Collaborative Study Group

❮ Previous
Next ❯

Citations

Feb 8, 2020·QJM : Monthly Journal of the Association of Physicians·R ChokesuwattanaskulW Cheungpasitporn

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.