Selective and pan-blockade agents in the anti-angiogenic treatment of proliferative diabetic retinopathy: a literature summary

Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
Gian P GiuliariRafael T Cortez

Abstract

Diabetes mellitus is a major health concern in the modern world. Several sight-threatening ocular conditions are included in the array of health problems associated with this disease. Understandably, 2 of the more sight-threatening problems, proliferative diabetic retinopathy (PDR) and diabetic macular edema (DME), have received a great deal of attention in recent years. Pivotal studies, such as the Early Treatment Diabetic Retinopathy Study and the Diabetic Retinopathy Study, have established laser photocoagulation as the accepted treatment modality. The last decade has seen a surge in clinical data supporting the use of pharmacologic therapy in place of the often damaging laser therapy. Supporting data are based on the establishment of vascular endothelial growth factor (VEGF) as a key facilitator of disease progression in diabetic retinopathy. We will discuss the advantages and disadvantages of both selective and pan-blockade anti-VEGF agents available today in an effort to help guide physicians wishing to use these agents to treat PDR and DME.

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Citations

May 26, 2011·Current Diabetes Reports·Jennifer T Durham, Ira M Herman
May 29, 2012·Current Diabetes Reports·Shuang WangElia J Duh
Feb 8, 2014·Ophthalmic Genetics·Rasha Mohamad Hosny ShahinMohamed El-Nady
Jun 30, 2011·Orvosi hetilap·Gábor Holló
Apr 20, 2012·Canadian Journal of Physiology and Pharmacology·Aneta Radziwon-BalickaPaul Jurasz
Nov 14, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Elizabeth A CairnsMelanie E M Kelly

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