Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats

Epilepsy Research
Erwin van VlietJan Gorter

Abstract

There is recent evidence that increased expression of multidrug transporters, such as P-glycoprotein (P-gp), may lead to reduced antiepileptic drug (AED) concentrations in the brain, shortly after status epilepticus (SE), thereby suggesting a possible mechanism for drug-resistance. To get insights on whether increased P-gp expression is a consequence of the initial insult, or evolves more gradually as a result of recurrent spontaneous seizures, we used a rat model of temporal lobe epilepsy in which spontaneous seizures develop after an electrically induced SE. We investigated the temporal and region-specific expression of two isoforms of the multidrug resistance gene (mdr1a and mdr1b, both encoding for P-gp) in two regions within the temporal lobe (the dentate gyrus (DG) and the parahippocampal cortex (PHC)). Using real-time PCR, we found that the mdr1b isoform was increased in the temporal lobe, 1 week after SE; however, this increase was reversible in dentate gyrus while it persisted in the parahippocampal cortex of chronic epileptic rats. Mdr1b upregulation was related to the occurrence of spontaneous seizures, since this isoform was unchanged in rats that were stimulated, but that did not develop SE (non-SE). The mdr1a isof...Continue Reading

References

Jun 23, 1998·The Journal of Biological Chemistry·G Zhou, M T Kuo
Mar 10, 2001·Biochemical and Biophysical Research Communications·M DemeuleR Béliveau
Aug 2, 2002·Epilepsy Research·Wolfgang Löscher, Dieter Schmidt
Oct 12, 2002·Carcinogenesis·Jason A Bush, Gang Li
Oct 24, 2002·Neuroreport·Patrizia BalleriniFrancesco Caciagli

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Citations

Apr 16, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Karin BoerEleonora Aronica
Sep 25, 2012·Journal of Veterinary Internal Medicine·K R MuñanaK L Mealey
Dec 3, 2009·Expert Review of Neurotherapeutics·Tiziana GranataDamir Janigro
Jul 15, 2005·Expert Opinion on Pharmacotherapy·Nicole SoranzoSanjay M Sisodiya
Dec 27, 2011·Advanced Drug Delivery Reviews·Chunbo ZhangLarry Baum
Dec 6, 2011·Advanced Drug Delivery Reviews·Eleonora AronicaJan A Gorter
Jul 21, 2010·Epilepsy Research·Linda HoltmanJan A Gorter
Dec 15, 2015·Fundamental & Clinical Pharmacology·Ricardo V SoaresStéphanie Chhun
Sep 3, 2008·Journal of Neurochemistry·Salah YousifXavier Declèves
May 5, 2011·Cardiovascular Psychiatry and Neurology·Nicola MarchiDamir Janigro
Jul 14, 2005·Progress in Neurobiology·Wolfgang Löscher, Heidrun Potschka
Aug 9, 2013·Molecular Pharmaceutics·Janine AvemaryHeidrun Potschka
Apr 5, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Holger VolkWolfgang Löscher
Mar 30, 2007·The Journal of Pharmacology and Experimental Therapeutics·E A van VlietJ A Gorter
Nov 2, 2019·Journal of Neuroinflammation·Chitra RawatRitushree Kukreti
Jul 22, 2017·Frontiers in Neurology·Fei TangBjörn Bauer
Dec 12, 2020·The European Journal of Neuroscience·Iman Imtiyaz Ahmed Juvale, Ahmad Tarmizi Che Has

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