Selective anti-tumor activity of wogonin targeting the Warburg effect through stablizing p53

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Yikai ZhaoNa Lu

Abstract

Most cancer cells generate energy through aerobic glycolysis to enable their rapid growth and proliferation, which is a phenomenon known as Warburg effect. Inhibition of aerobic glycolysis reduces lactate and ATP generation in cancer cells, and ultimately kills tumor cells. Increasing evidence suggests that wogonin, a flavonoid isolated from Scutellaria baicalensis Georgi, exhibits potent anti-tumor effects in vivo and in vitro. However, the role of wogonin in the aerobic glycolysis of tumor cells has not yet been elucidated. In this study, the effect of wogonin on glucose uptake, lactate generation and ATP content is assessed in colon, ovarian and hepatocellular cancer cells. The results indicate that wogonin reduces glycolysis and cell proliferation in cancer cells expressing wild-type p53 but not mutated p53. Wogonin increases the expression of p53 and p53-inducible glycolysis and apoptosis regulator (TIGAR), while decreases glucose transporter 1 (GLUT1) and some key glycolytic enzymes. Expressing wild-type and mutant-type p53 in HCT116 p53-/- cells proved that the inhibitory effect of wogonin on glycolysis in cancer cells is dependent on wild type p53. Mechanistically, wogonin induced the phosphorylation and acetylation of ...Continue Reading

Citations

Sep 2, 2019·Archives of Pharmacal Research·Maphuti T LebeloMichelle H Visagie
May 19, 2019·International Journal of Molecular Sciences·Hee-Sung ChaeHyungshin Yim
Jan 7, 2021·Cancers·Marek SamecPeter Kubatka
Apr 27, 2021·Frontiers in Pharmacology·Zaizhong WangJianhua Zhang
Jul 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Javad Sharifi-RadWilliam C Cho
Feb 2, 2022·Phytotherapy Research : PTR·Kishore BanikAjaikumar B Kunnumakkara

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