Selective Antimicrobial Activities and Action Mechanism of Micelles Self-Assembled by Cationic Oligomeric Surfactants

ACS Applied Materials & Interfaces
Chengcheng ZhouYilin Wang

Abstract

This work reports that cationic micelles formed by cationic trimeric, tetrameric, and hexameric surfactants bearing amide moieties in spacers can efficiently kill Gram-negative E. coli with a very low minimum inhibitory concentration (1.70-0.93 μM), and do not cause obvious toxicity to mammalian cells at the concentrations used. With the increase of the oligomerization degree, the antibacterial activity of the oligomeric surfactants increases, i.e., hexameric surfactant > tetrameric surfactant > trimeric surfactant. Isothermal titration microcalorimetry, scanning electron microscopy, and zeta potential results reveal that the cationic micelles interact with the cell membrane of E. coli through two processes. First, the integrity of outer membrane of E. coli is disrupted by the electrostatic interaction of the cationic ammonium groups of the surfactants with anionic groups of E. coli, resulting in loss of the barrier function of the outer membrane. The inner membrane then is disintegrated by the hydrophobic interaction of the surfactant hydrocarbon chains with the hydrophobic domains of the inner membrane, leading to the cytoplast leakage. The formation of micelles of these cationic oligomeric surfactants at very low concentrati...Continue Reading

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Citations

Nov 1, 2016·ACS Applied Materials & Interfaces·Chengcheng ZhouYilin Wang
Jun 2, 2017·ACS Applied Materials & Interfaces·Shuai ChenLidong Li
Jun 24, 2017·ACS Applied Materials & Interfaces·Yaxun FanYilin Wang
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Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Xiaowei ZhangYongjin Li
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Feb 7, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Ting ChenJinben Wang
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Apr 5, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Yaxun Fan, Yilin Wang
Jul 8, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Zhidi ChenYilin Wang
Apr 3, 2019·ACS Applied Materials & Interfaces·Junfang ZhangChunru Wang
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Nov 26, 2020·ACS Applied Materials & Interfaces·Seong-Cheol ParkDongwon Lee

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