Selective association of multiple sclerosis with infectious mononucleosis

Multiple Sclerosis : Clinical and Laboratory Research
B M ZaadstraJ M van Noort

Abstract

Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population-based case-control study involving 2,877 MS cases and 2,673 controls in the Netherlands. We examined the frequency of different common infections and afflictions before the age of 25 and the age at which they occurred, using a self-administered questionnaire. The Odds ratios (ORs) for the occurrence of a variety of clinically manifest common childhood infections including rubella, measles, chicken pox and mumps before the age of 25 for MS cases versus controls ranged between 1.14 and 1.42, values similar to those for irrelevant probe variables used to reveal recall bias. In contrast, the OR for clinically manifest IM in MS cases versus controls, corrected for demographic variables, was 2.22 (95% confidence interval 1.73 - 2.86; P < 0.001). The average age of onset of IM in the population of MS cases (16.5 years) did not differ from controls (16.8 years). Our data confirm previous much s...Continue Reading

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Citations

Apr 7, 2010·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Alberto Ascherio, Kassandra L Munger
Jun 30, 2010·Brain : a Journal of Neurology·Charles Pierrot-Deseilligny, Jean-Claude Souberbielle
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Mar 3, 2009·Journal of the Neurological Sciences·Jeroen J G GeurtsR Zivadinov
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Sep 12, 2014·Acta Neurologica Scandinavica·D JonsO Andersen
Dec 16, 2011·Virology·Hye-Ri KangMoon Jung Song
Nov 20, 2013·Journal of the Neurological Sciences·Carole A LunnyJennifer A Knopp-Sihota
Jan 8, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Mervi OikonenAimo Salmi
Nov 13, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Jonatan Salzer, Kjell-Morten Myhr
Nov 1, 2017·International Journal of Epidemiology·Eleanor SandersonGeorge Davey Smith
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Apr 1, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Hector S IzurietaRafael Harpaz

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