Selective autophagy mechanism against Group A Streptococcus infection

Nihon saikingaku zasshi. Japanese journal of bacteriology
Takashi Nozawa

Abstract

Autophagy acts as an intracellular host defense system against invading pathogenic microorganisms such as Group A Streptococcus (GAS). Autophagy is a membrane-mediated degradation system that is regulated by intracellular membrane trafficking regulators, including small GTPase Rab proteins. Here, we revealed Rab GTPase network that regulate autophagosome formation against GAS. A unique set of Rab GTPases coordinates autophagy to enable to form huge autophagosomes surrounding GAS by linking recycling endosomes and trans Golgi-network. We also found that NLRP4, one of intracellular pathogen recognition receptor, directs Rho signaling to facilitate autophagosome formation. In this article, we would like to show our findings on how host autophagy regulators coordinate autophagy during GAS infection.

References

Nov 6, 2004·Science·Ichiro NakagawaTamotsu Yoshimori
Jun 15, 2005·Cellular Microbiology·Maximiliano G GutierrezMaría I Colombo
Dec 4, 2009·PLoS Pathogens·Hitomi YamaguchiTamotsu Yoshimori
Jan 7, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nao JounaiFumihiko Takeshita
Jun 21, 2011·Cellular and Molecular Life Sciences : CMLS·Christelle En Lin ChuaBor Luen Tang
Jan 5, 2014·Nature Reviews. Microbiology·Ju Huang, John H Brumell
May 31, 2014·Nature Cell Biology·Alexandra StolzIvan Dikic
Aug 21, 2015·Nature Communications·Kevin MoreauDavid C Rubinsztein
Aug 30, 2017·The EMBO Journal·Atsuko Minowa-NozawaIchiro Nakagawa

❮ Previous
Next ❯

Citations

May 1, 2020·The Journal of Biological Chemistry·Rachel UnderwoodTalene A Yacoubian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

Autophagosome

An autophagosome is the formation of double-membrane vesicles that involve numerous proteins and cytoplasmic components. These double-membrane vesicles are then terminated at the lysosome where they are degraded. Discover the latest research on autophagosomes here.