Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs

Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie
Y HayashiI Yoshiya


Beta 2 as well as beta 1 adrenoceptors have been recognized in the heart of vertebrates. They mediate a positive chronotropic action of catecholamines. We compared the effect of selective beta 1 and beta 2 adrenoceptor antagonists on the genesis of halothane-epinephrine arrhythmias in dogs. The arrhythmogenic dose (AD) of epinephrine was increased in the presence of l-metoprolol, a selective beta 1 antagonist (8.40 +/- 1.13 x min-1; mean +/- SEM), compared with control value (2.62 +/- 0.56) (P < 0.05). In contrast, ICI-118,551, a selective beta 2 antagonist, did not change the AD (2.36 +/- 0.43). Adding ICI-118,551 to l-metoprolol did not affect the AD of epinephrine in the presence of l-metoprolol alone (6.34 +/- 0.74 vs 8.40 +/- 1.13). These results suggest that selective beta 1 blockade is effective in preventing halothane-epinephrine arrhythmias, but selective beta 2 blockade is not.


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Jul 3, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S TakahashiH Toyooka
Jan 1, 2003·Journal of Toxicology. Clinical Toxicology·Lewis S Nelson
Jul 12, 1995·Annals of the New York Academy of Sciences·Y HayashiI Yoshiya

Related Concepts

ICI 118551, hydrochloride
Adrenergic beta-Antagonists
Cardiac Arrhythmia
Diastolic Blood Pressure
Canis familiaris
Dose-Response Relationship, Drug
Epinephrine Acetate
Premature Cardiac Complex

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