Selective binding and transcytosis of Ulex europaeus 1 lectin by mouse Peyer's patch M-cells in vivo

Cell and Tissue Research
M A ClarkB H Hirst

Abstract

The in vivo interaction of the lectin Ulex europaeus agglutinin 1 with mouse Peyer's patch follicle-associated epithelial cells was studied in the mouse Peyer's patch gut loop model by immunofluorescence and electron microscopy. The lectin targets to mouse Peyer's patch M-cells and is rapidly endocytosed and transcytosed. These processes are accompanied by morphological changes in the M-cell microvilli and by redistribution of polymerised actin. The demonstration of selective binding and uptake of a lectin by intestinal M-cells in vivo suggests that M-cell-specific surface glycoconjugates might act as receptors for the selective adhesion/uptake of microorganisms.

References

Oct 1, 1992·Physiological Reviews·J P Kraehenbuhl, M R Neutra
Oct 13, 1989·Science·N Sharon, H Lis
Nov 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M A ClarkB H Hirst
Sep 1, 1994·Research in Microbiology·M A ClarkB H Hirst
May 1, 1992·Trends in Cell Biology·M R Neutra, J P Kraehenbuhl

❮ Previous
Next ❯

Citations

Jan 1, 1997·Springer Seminars in Immunopathology·I C Davis, R L Owen
Feb 11, 2011·Current Infectious Disease Reports·Shailja Tiwari, Suresh P Vyas
Dec 23, 2008·Archives of Pharmacal Research·Su-Yun Lyu, Won-Bong Park
Feb 19, 2004·Advanced Drug Delivery Reviews·Mark A JepsonBarry H Hirst
Apr 27, 2013·Comparative Immunology, Microbiology and Infectious Diseases·Christophe CasteleynChris Van Ginneken
Apr 9, 2005·International Journal of Pharmaceutics·Na ZhangWen F Xu
Sep 1, 2000·Advanced Drug Delivery Reviews·M A ClarkM A Jepson
Aug 8, 2001·Advanced Drug Delivery Reviews·M A ClarkB H Hirst
Jun 6, 2000·Advanced Drug Delivery Reviews·T H Ermak, P J Giannasca
Jan 28, 2003·Vaccine·Fabricio Medina-BolivarCarole L Cramer
May 20, 1998·Research in Immunology·B L Kelsall, W Strober
Mar 31, 2000·Trends in Cell Biology·F Niedergang, J P Kraehenbuhl
Jan 29, 2000·Immunology·E C LavelleD T O'Hagan
Feb 13, 2001·Immunology·E C LavelleD T O'Hagan
Dec 18, 2002·International Journal of Experimental Pathology·Angela KelsallR A Goodlad
Jun 5, 2007·Expert Review of Vaccines·Suresh P Vyas, Prem N Gupta
Jul 16, 2005·Expert Opinion on Biological Therapy·Michael Vajdy, Manmohan Singh
Jun 6, 2008·Expert Opinion on Drug Delivery·Rhonda Kuolee, Wangxue Chen
Nov 3, 2010·Journal of Drug Targeting·Barbara C Baudner, Derek T O'Hagan
Nov 22, 2005·Expert Opinion on Drug Delivery·Monjed ShakwehElias Fattal
Apr 16, 2010·Nutrition·Jin SunYong-Hui Shi
Apr 1, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabian ReuterAndreas Frey
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Miao WangYongguang Zhang
Sep 27, 2005·Acta histochemica·Eileen L HeinrichSteven B Oppenheimer
Dec 22, 2010·Biochemical and Biophysical Research Communications·Kazutaka TeraharaHiroshi Kiyono
Sep 29, 2009·Molecular Immunology·Siobhan B Cashman, John G Morgan
Feb 1, 2006·PLoS Pathogens·Mickey PentecostManuel R Amieva
Nov 19, 2010·PLoS Pathogens·Ali AziziJiri Mestecky
Apr 17, 2015·PLoS Computational Biology·Tae J LeeLingchong You
Nov 3, 2004·Advanced Drug Delivery Reviews·Andrea BudaMark A Jepson
May 20, 1999·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A Gebhard, A Gebert
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shogo MisumiShozo Shoji
Jun 21, 2020·Vaccines·Céline LemoineAnita Milicic

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.