PMID: 9192662Jun 24, 1997Paper

Selective binding of bacterial toxins to major histocompatibility complex class II-expressing cells is controlled by invariant chain and HLA-DM

Proceedings of the National Academy of Sciences of the United States of America
P M LavoieR P Sékaly

Abstract

Bacterial superantigens (SAgs) bind to major histocompatibility complex (MHC) class II molecules and activate T cells in a Vbeta-restricted fashion. We recently identified subsets of HLA-DR1 molecules that show selectivity for SAgs. Here, we extend these observations by showing that different cell lineages demonstrate distinct SAg-binding specificities although they all express HLA-DR1. Indeed, B cells bind staphylococcal enterotoxin A (SEA) and toxic shock syndrome toxin 1 (TSST-1) with high affinity while staphylococcal enterotoxin B (SEB) binding is barely detectable. In contrast, DR1-transfected HeLa cells show efficient binding of SEB, but not of SEA or TSST-1. We investigated the class II maturation events required for efficient interaction with SAgs and found that the ability of cells to bind and present the toxins can be drastically modulated by coexpression of the class II-associated invariant chain (Ii) and HLA-DM. SEA binding to DR1 molecules required coexpression of Ii, whereas TSST-1 binding was selectively enhanced by DM. Binding of SEB was affected by cell type-specific factors other than Ii or DM. The selectivity of SAgs for different MHC class II populations was minimally affected by HLA-DR intrinsic polymorphi...Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D R KarpE O Long
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A HermanR P Sekaly
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Citations

Apr 12, 2001·European Journal of Immunology·F A VerreckG J Hämmerling
Feb 22, 2002·Medicinal Research Reviews·Benjamin J McFarland, Craig Beeson
Mar 31, 2000·Immunologic Research·P E JensenC T Dao
May 1, 1997·Research in Immunology·J ThibodeauP A Cazenave
Jan 13, 2000·Immunological Reviews·P E JensenC T Dao
Dec 21, 2002·Tissue Antigens·H KhalilJ Thibodeau
Jan 15, 2000·Journal of Neuroimmunology·M Hassan-ZahraeeJ P Antel
Jul 10, 2009·PloS One·Kedar NarayanScheherazade Sadegh-Nasseri
Jun 24, 2005·International Immunology·Pascal M LavoieRafick-P Sékaly
Nov 20, 2001·The Journal of Biological Chemistry·Amélie FaubertJacques Thibodeau
Aug 31, 2000·The Journal of Biological Chemistry·A BrunetJ Thibodeau
Feb 2, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohammed M NoohMalak Kotb
Jan 24, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jean-Simon FortinJacques Thibodeau
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·P M LavoieJ Thibodeau
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Georges A AzarJacques Thibodeau
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina V PinchukVictor E Reyes
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T GolovkinaA Chervonsky

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