Selective blockade of a slowly inactivating potassium current in striatal neurons by (+/-) 6-chloro-APB hydrobromide (SKF82958)

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E S NisenbaumD J Surmeier

Abstract

The ion channels of rat striatal neurons are known to be modulated by stimulation of D1 dopamine receptors. The susceptibility of depolarization-activated K+ currents to be modulated by the D1 agonist, 6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetra-hydro-1H-3-benzaze pine (APB) was investigated using whole-cell voltage-clamp recording techniques from acutely isolated neurons. APB (0.01-100 microM) produced a concentration-dependent reduction in the total K+ current. At intermediate concentrations (ca. 10 microM), APB selectively depressed the slowly inactivating A-current (I(As)). A similar effect was produced by application of the D1 agonist, 7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1-H-2-benzazepine (SKF38393, 10 microM). APB reduced I(As) rapidly, having onset and recovery time constants of 1.2 sec and 1.6 sec, respectively. Unexpectedly, the effect of APB could not be mimicked by application of Sp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Sp-cAMPS, 100-200 microM), a membrane-permeable analog of cyclic AMP (cAMP), or by pretreatment with forskolin (25 microM), an activator of adenylyl cyclase. The reduction in I(As) also was not blocked by pretreatment with the D1 receptor antagonist, R(+)-SCH23390 hy...Continue Reading

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Citations

Apr 30, 2009·Annual Review of Neuroscience·Anatol C Kreitzer
Mar 13, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M Lalley
Nov 27, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yuki HayashidaAndrew T Ishida
Apr 12, 2007·Proceedings of the National Academy of Sciences of the United States of America·Marc WelterEmiliana Borrelli
Jun 9, 2000·Annual Review of Neuroscience·S M NicolaR C Malenka
Jan 1, 2013·F1000Research·Gabriele Scheler
Jan 1, 2013·F1000Research·Gabriele Scheler
Oct 13, 2006·Neurochemical Research·Elizabeth Hernández-EcheagarayMichael S Levine
Dec 6, 2002·Journal of Neurophysiology·Jorge Flores-HernándezMichael S Levine
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Barbara L WaszczakJames R Stellar
Jun 4, 2004·The Journal of Pharmacology and Experimental Therapeutics·Sanjida S SaklayenElizabeth A Pehek
Mar 11, 2000·Journal of Neurophysiology·D DurstewitzT J Sejnowski
Aug 8, 2021·Nature Communications·Prashant DonthamsettiEhud Isacoff

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