Selective bowel decontamination of recipients for prevention against liver injury following orthotopic liver transplantation: evaluation with rat models

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M AraiK Fujiwara

Abstract

Gut-derived substances can activate Kupffer cells to provoke hepatic necrosis after partial hepatectomy in rats. A similar situation may occur during orthotopic liver transplantation (OLT), as congestion in the intestinal wall, caused by portal vein occlusion, is inevitable during the operation. The contribution of such substances to liver injury following OLT was investigated in rats. Oral administration of polymyxin B sulfate for 7 days significantly altered intestinal bacterial flora in rats; Enterobacteriaceae diminished and anaerobes such as Bifidobacterium , Lactobacillus, Bacteroides, and Eubacterium increased in number, compared with the control rats. Also, this treatment significantly reduced endotoxin concentration in the portal blood 30 minutes after blood reflow following portal vein occlusion. When OLT was performed in rats using the liver preserved in cold University of Wisconsin solution for 18 hours, tissue factor activity in Kupffer cells (KC) isolated from the transplanted liver 1 hour after the operation was significantly higher than in that of normal rats. This increase was significantly reduced by pretreatment of the recipients with polymyxin B sulfate. In these recipients, serum alanine aminotransferase ac...Continue Reading

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Citations

Jul 12, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Masakazu NittaEizou Watanabe
Apr 30, 1999·Transplantation·K J OldhaferR Pichlmayr
Feb 18, 2010·Transplantation·Yoichiro UchidaJerzy W Kupiec-Weglinski
Jul 12, 2002·Journal of Gastroenterology·Kenji Fujiwara, Satoshi Mochida
Aug 11, 2015·Journal of Hepatology·Hui-Xin LiuYu-Jui Yvonne Wan
Sep 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ryan N FioriniKenneth D Chavin
Jul 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yoichiro UchidaJerzy W Kupiec-Weglinski
Sep 29, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Francesco D'AmicoUmberto Cillo
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Dec 31, 2020·International Journal of Molecular Sciences·Marc Micó-CarneroCarmen Peralta

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