PMID: 1034177Nov 1, 1976

Selective breeding of rats for differences in reactivity to alcohol. An approach to an animal model of alcoholism. I. General procedures

Journal of Studies on Alcohol
E P RileyD Lester


Strains of rats are being developed which have distinct responses in spontaneous locomotor activity to a subhypnotic dose of alcohol. The purpose is to produce one strain in which the injection of a standard dose of alcohol will result in objectively measurable intoxication and a second in which an identical dose will result in virtually no effect.


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Related Concepts

Alcoholic Intoxication
Alcohol Abuse
Dose-Response Relationship, Drug
Injections, Intraperitoneal
Selection, Genetic

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