Selective cerebral vascular dysfunction in Mn-SOD-deficient mice

Journal of Applied Physiology
Frank M FaraciSean P Didion

Abstract

We tested the hypothesis that the mitochondrial form of superoxide dismutase [manganese superoxide dismutase (Mn-SOD)] protects the cerebral vasculature. Basilar arteries (baseline diameter approximately 140 microm) from mice were isolated, cannulated, and pressurized to measure vessel diameter. In arteries from C57BL/6 mice preconstricted with U-46619, acetylcholine (ACh; an endothelium-dependent vasodilator) produced dilation that was similar in male and female mice and abolished by an inhibitor of nitric oxide synthase. Vasodilation to ACh was not altered in heterozygous male or female Mn-SOD-deficient (Mn-SOD+/-) mice compared with wild-type littermate controls (Mn-SOD+/+). Constriction of the basilar artery to arginine vasopressin, but not KCl or U-46619, was increased in Mn-SOD+/- mice (P<0.05), and this effect was prevented by tempol, a scavenger of superoxide. We also examined responses of cerebral (pial) arterioles (branches of the middle cerebral artery, control diameter approximately 30 microm) to ACh in anesthetized mice using a cranial window. Responses to ACh, but not nitroprusside (an endothelium-independent agonist), were reduced (P<0.05) in cerebral arterioles in Mn-SOD+/- mice, and this effect was prevented by...Continue Reading

References

Aug 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T ItakuraN Komai
Aug 1, 1986·Acta Neurologica Scandinavica·P S Sørensen
Apr 1, 1997·Stroke; a Journal of Cerebral Circulation·C G Sobey, F M Faraci
Jul 1, 1997·Stroke; a Journal of Cerebral Circulation·W I Rosenblum
Feb 11, 1998·Physiological Reviews·F M Faraci, D D Heistad
Dec 11, 1999·Circulation Research·F M Faraci, C D Sigmund
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·M YamadaJ Wess
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K NiwaC Iadecola
Mar 27, 2002·Methods in Enzymology·Ting-Ting HuangCharles J Epstein
Jul 31, 2002·Circulation·Scott W BallingerMarschall S Runge
Nov 16, 2002·Circulation Research·Sean P DidionFrank M Faraci
Jun 21, 2003·Circulation Research·Kerstin StrehlowGeorg Nickenig
Oct 29, 2003·Antioxidants & Redox Signaling·Taku Sugawara, Pak H Chan
Mar 24, 2004·Trends in Genetics : TIG·Nobuyuki Takahashi, Oliver Smithies
May 29, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Frank M Faraci, Sean P Didion
Jun 26, 2004·Stroke; a Journal of Cerebral Circulation·Sean P DidionFrank M Faraci
Aug 20, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jon J AndresenDonald D Heistad
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Cornelius F H MuellerDavid G Harrison
Nov 6, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Sean P Didion, Frank M Faraci
Nov 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nageswara R MadamanchiMarschall S Runge
Nov 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Frank M FaraciKathryn G Lamping
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Changdong YanDong Sun
Jan 8, 2005·Stroke; a Journal of Cerebral Circulation·Sean P DidionFrank M Faraci
Jan 18, 2005·Stroke; a Journal of Cerebral Circulation·Frank M Faraci
Aug 12, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Frank M FaraciSean P Didion

❮ Previous
Next ❯

Citations

Dec 30, 2008·Pharmacological Reviews·Christopher S Wilcox, Adam Pearlman
Apr 28, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Mary L ModrickFrank M Faraci
Mar 23, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Jordan D MillerDonald D Heistad
Feb 22, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Frank M Faraci
May 26, 2012·Journal of Applied Physiology·Sophocles ChrissobolisFrank M Faraci
Jul 30, 2010·PloS One·Luca GoitreSaverio Francesco Retta
May 26, 2012·Canadian Journal of Physiology and Pharmacology·Chris R TriggleHong Ding
Jan 21, 2016·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Mohammed H AbdullaEdward J Johns
Oct 22, 2008·Trends in Molecular Medicine·Sophocles Chrissobolis, Frank M Faraci
Mar 19, 2016·Cellular and Molecular Neurobiology·T Michael De Silva, Frank M Faraci
Sep 24, 2013·Journal of Neuroscience Methods·Sahar GhanavatiJohn G Sled
Apr 8, 2010·Clinical Science·Alyson A MillerChristopher G Sobey
May 17, 2011·Free Radical Biology & Medicine·Nirmala ParajuliLee Ann Macmillan-Crow
Apr 9, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mary L ModrickFrank M Faraci
Nov 24, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Sean P DidionFrank M Faraci
Dec 19, 2015·Physiological Reviews·Xin Gen LeiElias S J Arnér
Sep 30, 2020·Maternal & Child Nutrition·Ilana R ClifferBeatrice L Rogers
Jul 13, 2012·Journal of Neurochemistry·Anantha Vijay R SanthanamZvonimir S Katusic
Mar 19, 2009·Pharmacological Reviews·Noboru TodaTomio Okamura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Frank M FaraciSean P Didion
Arteriosclerosis, Thrombosis, and Vascular Biology
Frank M Faraci, Sean P Didion
© 2021 Meta ULC. All rights reserved