Selective chemical binding enhances cesium tolerance in plants through inhibition of cesium uptake

Scientific Reports
Eri AdamsRyoung Shin

Abstract

High concentrations of cesium (Cs(+)) inhibit plant growth but the detailed mechanisms of Cs(+) uptake, transport and response in plants are not well known. In order to identify small molecules with a capacity to enhance plant tolerance to Cs(+), chemical library screening was performed using Arabidopsis. Of 10,000 chemicals tested, five compounds were confirmed as Cs(+) tolerance enhancers. Further investigation and quantum mechanical modelling revealed that one of these compounds reduced Cs(+) concentrations in plants and that the imidazole moiety of this compound bound specifically to Cs(+). Analysis of the analogous compounds indicated that the structure of the identified compound is important for the effect to be conferred. Taken together, Cs(+) tolerance enhancer isolated here renders plants tolerant to Cs(+) by inhibiting Cs(+) entry into roots via specific binding to the ion thus, for instance, providing a basis for phytostabilisation of radiocesium-contaminated farmland.

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Feb 27, 2013·International Journal of Molecular Sciences·Eri AdamsRyoung Shin
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Citations

Dec 4, 2020·International Journal of Molecular Sciences·Eri AdamsRyoung Shin

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Methods Mentioned

BETA
genetic
chemical treatment
genetic modification

Software Mentioned

Gaussian
Prism
GraphPad

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