Selective chemokine mRNA expression following brain injury

Brain Research
E H HausmannR M Klein

Abstract

Injury in non-neuronal tissues stimulates chemokine expression leading to recruitment of inflammatory cells responsible for orchestration of repair processes. The signals involved in directing repair of damage to the brain are less well understood. We hypothesized that following brain injury, chemokines are expressed and regulate the rate and pattern of inflammatory cell accumulation. The two chemokine subfamilies are alpha(alpha)-chemokines, which primarily function as neutrophil chemoattractants, and the beta(beta)-chemokines, which function primarily as monocyte chemoattractants. We assessed alpha and beta chemokine mRNA expression patterns and leukocyte accumulation following a cerebral cortical lesion. Cortical lesions were produced with and without addition of endotoxin, Escherichia coli lipopolysaccharide (LPS), which stimulates cytokine expression. We studied the expression of the beta-chemokines: monocyte chemoattractant protein (gene product JE; MCP-1/JE), macrophage inflammatory protein-1 alpha and beta (MIP-1alpha and MIP-1beta), and the regulated upon activation normal T expressed and secreted chemokine (RANTES) as well as the alpha-chemokines: interferon-gamma-inducible protein (IP-10) and N51/KC (KC; a murine hom...Continue Reading

References

Oct 1, 1992·Neuropathology and Applied Neurobiology·V H Perry, P B Andersson
May 1, 1991·Cytokine·T J Schall
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Jun 26, 1990·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W L MaxwellM Berry
Jan 15, 1991·Brain Research. Developmental Brain Research·K Ashwell
Dec 1, 1990·Journal of Neuroimmunology·D MaleJ Rahman
Dec 1, 1990·Journal of the Neurological Sciences·R D Simmons, D O Willenborg
May 16, 1990·Biochemical and Biophysical Research Communications·Y Ohmori, T A Hamilton
Nov 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W J Streit
Aug 1, 1990·The Journal of Experimental Medicine·O RamiloG H McCracken
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·B S KwonS M Weissman
Aug 1, 1988·The Journal of Pathology·W L MaxwellT A Gennarelli
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B J RollinsC D Stiles
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon
Jun 1, 1995·Journal of Neurocytology·D XieE F Whitter
Jan 1, 1994·Annual Review of Neuroscience·D M Landis
Apr 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R M RansohoffV K Tuohy
May 1, 1996·Journal of the Neurological Sciences·J S Kim
Feb 1, 1997·The Journal of Infectious Diseases·P K PetersonC C Chao

❮ Previous
Next ❯

Citations

Mar 14, 2002·Journal of Neuroscience Research·David A MatzilevichPramod K Dash
Nov 27, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·David Cederberg, Peter Siesjö
Jun 8, 2006·Cellular and Molecular Neurobiology·Yasuko Sakurai-YamashitaMasami Niwa
Jan 15, 2013·Molecular Neurobiology·Menaka C ThounaojamAnirban Basu
Apr 2, 1999·Trends in Pharmacological Sciences·F MennickenR Quirion
Oct 26, 1999·Trends in Neurosciences·V C Asensio, I L Campbell
Mar 14, 2013·ACS Chemical Neuroscience·Thaddeus W VasicekJulie A Stenken
Nov 9, 2002·The Journal of Infectious Diseases·W Michael ScheldHans-Walter Pfister
Sep 19, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Andrzej R GlabinskiRichard M Ransohoff
Mar 26, 2009·Journal of Neurotrauma·Charlotte IsraelssonTed Ebendal
May 16, 2000·Critical Care Medicine·E R Sherwood, D S Prough
Apr 25, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Ying ShenYi-Dong Wu
Oct 22, 2005·Journal of Perinatal Medicine·Tian-Ming YuanJian-Ping Li
May 2, 2008·Journal of Neurosurgery·Roberto StefiniNicola Latronico
Mar 28, 2013·International Journal of Medical Sciences·Yu Lin, Liang Wen
Sep 7, 2000·Neuropharmacology·E Tavares, F J Miñano
Jan 8, 2016·Brain Research·Sarah HellewellMaria Cristina Morganti-Kossmann
Feb 3, 2009·Brain Research Bulletin·Emmanuel George VrotsosKiminobu Sugaya
Nov 12, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bridgette D SempleMaria Cristina Morganti-Kossmann
Dec 24, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Bridgette D SempleM Cristina Morganti-Kossmann
Apr 5, 2003·Acta Neurologica Scandinavica·M R Ardehali, G Rondouin
Apr 3, 2008·Journal of Neuroscience Research·Craig T AjmoKeith R Pennypacker
Mar 6, 2012·Journal of Neurochemistry·Silvia Di PriscoAnna Pittaluga
May 1, 2013·European Journal of Immunology·Christine L HsiehWilliam E Seaman

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