PMID: 275834Jun 1, 1978Paper

Selective complexing of the "nuclear" 5S estradiol receptor by a serum component, 5S-CA

Proceedings of the National Academy of Sciences of the United States of America
T O Fox

Abstract

A component present in several sera interacts selectively with the 5S "nuclear" form of estradiol receptor but not with the 4S "cytosol" form. This component is therefore referred to as "5S-complexing activity (5S-CA)." This selective interaction occurs with 5S receptor from mouse, calf, or rat. In addition, 5S-CA recognizes the nuclear form of the receptor from hypothalamic as well as uterine tissue Thus, 5S-CA indicates a general similarity in the chemical nature of 5S nuclear receptors prepared from several sources. Using 5S-CA as a chemical probe for the nuclear form of the estradiol receptor, I have shown the chemical as well as physical similarity of 5S receptors prepared in vivo (by injection of [3H]estradiol and subsequent isolation from nuclear/myofibrillar extracts) and in vitro (by labeling of cytoplasmic extracts and subsequent chromatography on columns of DNA-cellulose). These results indicate a distinctive chemical property of nuclear 5S forms of estradiol receptor. The data are interpreted with regard to models for 5S receptor formation. 5S-CA was found in sera from animals immunized against various antigens. The importance of testing for 5S-CA in antisera directed against steroid derivatives, steroid receptors, ...Continue Reading

References

May 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J UrielM Dupiers
Jun 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·C RadanyiH Richard-Foy
Jan 1, 1976·Annual Review of Physiology·J Gorski, F Gannon
Jan 1, 1976·Annual Review of Biochemistry·K R Yamamoto, B M Alberts
Sep 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G L GreeneE V Jensen
Nov 1, 1976·Journal of Steroid Biochemistry·A C NotidesE K Muechler
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·K R Yamamoto, B M Alberts
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Jun 20, 1972·Biochemistry·G C Chamness, W L McGuire
Feb 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·E V JensenE R DeSombre

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Citations

Oct 1, 1982·Journal of Steroid Biochemistry·S J Wieland, T O Fox
Mar 1, 1986·Journal of Steroid Biochemistry·A D LinstedtR M Brenner
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·H J Eisen
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S Liao, D Witte
Jun 30, 1987·Biochemical and Biophysical Research Communications·M Feldman
Jun 1, 1983·Hoppe-Seyler's Zeitschrift für physiologische Chemie·H H Meyer, P W Jungblut

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