Selective Conditions for a Multidrug Resistance Plasmid Depend on the Sociality of Antibiotic Resistance

Antimicrobial Agents and Chemotherapy
Michael J BotteryMichael A Brockhurst

Abstract

Multidrug resistance (MDR) plasmids frequently carry antibiotic resistance genes conferring qualitatively different mechanisms of resistance. We show here that the antibiotic concentrations selecting for the RK2 plasmid inEscherichia colidepend upon the sociality of the drug resistance: the selection for selfish drug resistance (efflux pump) occurred at very low drug concentrations, just 1.3% of the MIC of the plasmid-free antibiotic-sensitive strain, whereas selection for cooperative drug resistance (modifying enzyme) occurred at drug concentrations exceeding the MIC of the plasmid-free strain.

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Citations

Sep 1, 2017·FEMS Microbiology Ecology·Xinlei JiangTerrence C K Lau
Apr 25, 2018·Nature Communications·Erik Wistrand-YuenDan I Andersson
Mar 24, 2017·Nucleic Acids Research·Pilong LiuXin Zhao
Mar 23, 2018·The ISME Journal·Isabel FrostKevin R Foster
Sep 12, 2017·Nature Ecology & Evolution·Michael J BotteryMichael A Brockhurst
Oct 3, 2020·Evolutionary Applications·Shota Shibasaki, Sara Mitri
Nov 22, 2020·The ISME Journal·Michael J BotteryVille-Petri Friman
Jan 30, 2021·Computational and Structural Biotechnology Journal·Martin Zwanzig
Aug 28, 2021·Evolution, Medicine, and Public Health·Siobhán O'BrienAlex R Hall
Oct 11, 2021·The ISME Journal·Michael J BotteryVille-Petri Friman

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