Selective constraints on protamine 2 in primates and rodents

BMC Evolutionary Biology
Lena LükeEduardo R S Roldan

Abstract

Protamines are sperm nuclear proteins with a crucial role in chromatin condensation. Their function is strongly linked to sperm head morphology and male fertility. Protamines appear to be affected by a complex pattern of selective constraints. Previous studies showed that sexual selection affects protamine coding sequence and expression in rodents. Here we analyze selective constraints and post-copulatory sexual selection acting on protamine 2 (Prm2) gene sequences of 53 species of primates and rodents. We focused on possible differences in selective constraints between these two clades and on the two functional domains of PRM2 (cleaved- and mature-PRM2). We also assessed if and how changes in Prm2 coding sequence may affect sperm head dimensions. The domain of Prm2 that is cleaved off during binding to DNA (cleaved-Prm2) was found to be under purifying selection in both clades, whereas the domain that remains bound to DNA (mature-Prm2) was found to be positively selected in primates and under relaxed constraint in rodents. Changes in cleaved-Prm2 coding sequence are significantly correlated to sperm head width and elongation in rodents. Contrary to expectations, a significant effect of sexual selection was not found on either ...Continue Reading

References

May 1, 1975·The Journal of Cell Biology·A L Kierszenbaum, L L Tres
Nov 1, 1992·Biological Reviews of the Cambridge Philosophical Society·E R RoldanA D Vitullo
Mar 1, 1992·European Journal of Biochemistry·M ChauvièreP Chevaillier
Mar 22, 1991·Proceedings. Biological Sciences·M Gomendio, E R Roldan
Jan 1, 1991·Progress in Nucleic Acid Research and Molecular Biology·R Oliva, G H Dixon
Jan 1, 1988·Journal of Molecular Evolution·S A Krawetz, G H Dixon
Sep 1, 1985·Journal of Reproduction and Fertility·J M Cummins, P F Woodall
May 1, 1982·The Journal of Cell Biology·R Balhorn
May 1, 1994·Biology of Reproduction·A PirhonenP H Mäenpää
Jan 1, 1993·Molecular Reproduction and Development·I A BelokopytovaV I Vorob'ev
Dec 19, 1995·Proceedings of the National Academy of Sciences of the United States of America·K LeeR E Braun
Jul 1, 1997·Molecular Biology and Evolution·Z Yang, B Rannala
Feb 25, 1998·Proceedings. Biological Sciences·M J Gage
Mar 11, 2000·Molecular Biology and Evolution·A P RooneyM Nei
Apr 26, 2000·Molecular Biology and Evolution·J M Seddon, P R Baverstock
Jan 17, 2002·Evolution; International Journal of Organic Evolution·F J Rohlf
Mar 7, 2003·Biology of Reproduction·Chunghee ChoEdward M Eddy
Mar 20, 2003·Molecular Phylogenetics and Evolution·Ronald M AdkinsRodney L Honeycutt
Apr 8, 2003·Molecular Phylogenetics and Evolution·Michael E Steiper, Maryellen Ruvolo
Apr 16, 2004·American Journal of Physical Anthropology·Céline Poux, Emmanuel J P Douzery
Oct 19, 2004·Physiology & Behavior·Alan F Dixson, Matthew J Anderson
Jun 7, 2005·Molecular Phylogenetics and Evolution·Jinchuan XingMark A Batzer
Jul 19, 2005·Proceedings. Biological Sciences·Steven A RammPaula Stockley
Jan 10, 2006·Science·Warren E JohnsonStephen J O'Brien
Apr 4, 2006·Human Reproduction Update·Rafael Oliva
Nov 15, 2006·BMC Evolutionary Biology·Robin M D BeckAndy Purvis
Dec 7, 2006·Biology Letters·Aurelio F MaloEduardo R S Roldan
Jan 9, 2007·Human Reproduction Update·Douglas T CarrellSue Hammoud
Jan 27, 2007·BMC Evolutionary Biology·Karl M Kjer, Rodney L Honeycutt
Mar 14, 2007·Evolution; International Journal of Organic Evolution·Holger Herlyn, Hans Zischler
Mar 30, 2007·Nature·Olaf R P Bininda-EmondsAndy Purvis
May 8, 2007·Molecular Biology and Evolution·Ziheng Yang

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Citations

Sep 1, 2018·Systems Biology in Reproductive Medicine·Rod BalhornMonique C Balhorn
Mar 29, 2019·Andrology·T R S HamiltonM E O A Assumpção
May 26, 2018·Anatomia, histologia, embryologia·Klaus Steger, Rod Balhorn
Apr 29, 2019·Chromosoma·Peera Wasserzug-Pash, Michael Klutstein
Jun 10, 2020·BMC Evolutionary Biology·Lena ArévaloEduardo R S Roldan
Apr 22, 2021·Physiological Reviews·Maria Eugenia Teves, Eduardo R S Roldan
Jul 6, 2021·Evolution; International Journal of Organic Evolution·Lena ArévaloEduardo R S Roldan

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Software Mentioned

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PAML
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