Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice

Arteriosclerosis, Thrombosis, and Vascular Biology
Victoria L KingCharles D Loftin

Abstract

Inflammation plays an integral role in the development of abdominal aortic aneurysms (AAAs), and the expression of cyclooxygenase (COX)-2 is increased in aneurysmal tissue compared with normal aorta. Nonsteroidal anti-inflammatory drugs, which inhibit the activity of COX-1 and COX-2, decrease AAA expansion in humans and animal models of the disease. In the current study, we investigated the effectiveness of selective inhibition of COX-1 or COX-2 in attenuating AAA formation. Eight-week-old male apolipoprotein E-deficient mice were treated with selective inhibitors of COX-1 or COX-2, SC-560 (approximately 25 mg.kg(-1).day(-1)), or celecoxib (approximately 125 mg.kg(-1).day(-1)), respectively. COX inhibitors were administered 1 week before angiotensin II (Ang II; 1000 ng.kg(-1).min(-1)) or saline infusion and throughout the time course of the experiment. COX-1 inhibition had no effect on incidence (control: 90% [9:10] versus SC-560: 89% [8:9]) or severity of Ang II-induced AAA formation. In contrast, celecoxib decreased the incidence (control: 74% [22:30] versus celecoxib: 11% [2:19]; P<0.001) and severity (P=0.001) of AAA formation. Celecoxib also decreased the incidence and severity of AAAs in nonhyperlipidemic mice. COX-2-deri...Continue Reading

References

Jun 1, 1996·The Journal of Surgical Research·D R HolmesJ M Reilly
May 1, 1997·Journal of Vascular Surgery·D R HolmesJ M Reilly
Jun 7, 2000·The Journal of Clinical Investigation·A DaughertyL A Cassis
Jun 8, 2000·Annals of the New York Academy of Sciences·A Daugherty, L Cassis
Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·D PraticòG A FitzGerald
Apr 3, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N A CallejasP Martín-Sanz
Aug 7, 2002·British Journal of Pharmacology·Klaus HöcherlArmin Kurtz
Oct 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Zhuo-Wei HuBrian B Hoffman
May 28, 2003·Journal of the American College of Cardiology·Orina Belton, Desmond Fitzgerald
Jul 12, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Kiran SaraffAlan Daugherty
Jan 14, 2004·Hypertension·Helene FrancoisThomas M Coffman
Mar 17, 2004·The Journal of Biological Chemistry·K M Faisal KhanDomenick J Falcone
Jun 24, 2004·Circulation·Anthony R BradyUNKNOWN UK Small Aneurysm Trial Participants
Nov 13, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Zhanjun GuanJennifer L Hall
Jan 19, 2005·British Journal of Pharmacology·Lisa A CassisAlan Daugherty

❮ Previous
Next ❯

Citations

May 25, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hiroki AokiMasunori Matsuzaki
Feb 9, 2008·World Journal of Surgery·Suman AnnambhotlaChangyi Chen
Sep 3, 2010·Cardiovascular Drugs and Therapy·Jonathan GolledgeCatherine Rush
Jul 27, 2012·Current Atherosclerosis Reports·Hong LuAlan Daugherty
May 14, 2008·Current Hypertension Reports·Hong LuAlan Daugherty
Oct 25, 2008·Cardiovascular Research·Jonathan M Gitlin, Charles D Loftin
May 21, 2009·Cardiovascular Research·Takashi Miyake, Ryuichi Morishita
Mar 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Lisa A CassisAlan Daugherty
Sep 26, 2012·Hypertension·Christina S BartlettRichard M Breyer
Mar 13, 2012·The Journal of Clinical Investigation·Wen-Liang SongGarret A FitzGerald
May 10, 2012·PloS One·Utako YokoyamaYoshihiro Ishikawa
Aug 2, 2012·Mediators of Inflammation·Stacy L Dorris, R Stokes Peebles
Apr 25, 2012·Mediators of Inflammation·Zong-Zhuang Li, Qiu-Yan Dai
Jan 1, 2010·Expert Opinion on Drug Discovery·Hirofumi RokutanJochen Springer
Mar 8, 2013·Kidney International·Hester HappéDorien J M Peters
Dec 22, 2006·Annals of the New York Academy of Sciences·Alan DaughertyLisa A Cassis
May 10, 2007·Journal of Cellular and Molecular Medicine·Cristiana GriffoniVittorio Tomasi
Jul 29, 2011·Journal of Zhejiang University. Science. B·Alan DaughertyHong Lu
Oct 24, 2007·The Journal of Surgical Research·Shushan JacobSusan Lanza-Jacoby
Oct 18, 2013·Journal of Lipid Research·Mercedes CamachoLuis Vila
Apr 22, 2017·British Journal of Pharmacology·Qishan ChenLi Zhang
Sep 28, 2017·Journal of Cardiovascular Pharmacology·Shi-Lan ZhangLing Liu
Jan 20, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Austin C BoeseMilton H Hamblin
Jun 6, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Jing LiuAlan Daugherty
May 26, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Hong Lu, Alan Daugherty
Mar 26, 2013·Circulation Research·Darshini B TrivediRobert Langenbach
Jan 16, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Michael L McCormickNeal L Weintraub
Sep 16, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Jonathan GolledgePaul Norman
Apr 22, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·David Bishop-BaileyTimothy D Warner
Aug 21, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Goran MarinkovicVivian de Waard
Jun 6, 2009·Obesity·Victoria L KingLisa R Tannock
Aug 14, 2009·Expert Review of Cardiovascular Therapy·Ahmed N Assar
Jan 1, 2012·Current Protocols in Mouse Biology·Vivian de WaardCarlie J M de Vries
Jul 23, 2019·Journal of Cellular and Molecular Medicine·Bin LiuXiao Meng
Jun 19, 2013·Pharmacological Reviews·Utako YokoyamaYoshihiro Ishikawa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aortic Aneurysm

An aortic aneurysm is the weakening and bulging of the blood vessel wall in the aorta. This causes dilatation of the aorta, which is usually asymptomatic but carries the risk of rupture and hemorrhage. Find the latest research on aortic aneurysms here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Aneurysm

Aneurysms are outward distensions or bulges that occurs in a weakened wall of blood vessels. Discover the latest research on aneurysms here.