PMID: 11926564Apr 3, 2002Paper

Selective cyclooxygenase-2 inhibitors: after the smoke has cleared

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
J L Wallace

Abstract

An enormous amount of fanfare and marketing preceded the introduction of selective inhibitors of cyclooxygenase-2 to the marketplace. These drugs were purported to offer equivalent anti-inflammatory and analgesic effects to conventional non-steroidal anti-inflammatory drugs without causing gastrointestinal injury. Now that there is considerable clinical experience with four drugs of this class having been available for at least two years, it is worthwhile re-visiting some of the original claims to determine whether selective cyclooxygenase-2 inhibitors have thus far lived up to their promise. In short, selective cyclooxygenase-2 inhibitors have proven to be somewhat safer in terms of gastrointestinal toxicity, than some (but not all) conventional non-steroidal antiinflammatory drugs. However their efficacy of the selective cyclooxygenase inhibitors has not always matched that of the conventional nonsteroidal anti-inflammatory drugs and there are significant safety concerns with some of the new drugs that deserve very careful consideration.

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Citations

Jan 25, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M RatheeshAntony Helen
Apr 22, 2005·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·F RadaelliG Minoli
Oct 19, 2010·Gastroenterology Clinics of North America·Carmelo Scarpignato, Richard H Hunt
Oct 20, 2009·European Journal of Pharmacology·Yulan XiongYimin Jiang
Jul 7, 2007·Veterinary Immunology and Immunopathology·Rachael E EckertSamuel L Jones
Jul 19, 2005·Prostaglandins, Leukotrienes, and Essential Fatty Acids·John L WallaceStefano Fiorucci
Mar 15, 2005·Anesthesiology Clinics of North America·Noor M Gajraj, Girish P Joshi
Nov 9, 2016·BMC Medicine·Carmelo ScarpignatoUNKNOWN Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of Gene
Mar 16, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Tadeusz BalcerzakMichal Jaščur
Aug 16, 2005·Journal of Advanced Nursing·Eleanor BradleyPeter Nolan
May 23, 2003·Anesthesia and Analgesia·Noor M Gajraj

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