Selective Cytotoxic Activity of Prodigiosin@halloysite Nanoformulation

Frontiers in Bioengineering and Biotechnology
Ivan GuryanovRawil Fakhrullin

Abstract

Prodigiosin, a bioactive secondary metabolite produced by Serratia marcescens, is an effective proapoptotic agent against various cancer cell lines, with little or no toxicity toward normal cells. The hydrophobicity of prodigiosin limits its use for medical and biotechnological applications, these limitations, however, can be overcome by using nanoscale drug carriers, resulting in promising formulations for target delivery systems with great potential for anticancer therapy. Here we report on prodigiosin-loaded halloysite-based nanoformulation and its effects on viability of malignant and non-malignant cells. We have found that prodigiosin-loaded halloysite nanotubes inhibit human epithelial colorectal adenocarcinoma (Caco-2) and human colon carcinoma (HCT116) cells proliferative activity. After treatment of Caco-2 cells with prodigiosin-loaded halloysite nanotubes, we have observed a disorganization of the F-actin structure. Comparison of this effects on malignant (Caco-2, HCT116) and non-malignant (MSC, HSF) cells suggests the selective cytotoxic and genotoxic activity of prodigiosin-HNTs nanoformulation.

References

Apr 10, 1999·Molecular Biology of the Cell·A M YvonM A Jordan
Feb 7, 2003·Current Cancer Drug Targets·Beatriz Montaner, Ricardo Pérez-Tomás
Oct 14, 2003·Biochemical Pharmacology·Ricardo Pérez-TomásVanessa Soto-Cerrato
Jan 18, 2005·Biochemical Pharmacology·Jing ZhangDongzhi Wei
Nov 17, 2006·Nature Reviews. Microbiology·Neil R WilliamsonGeorge P C Salmond
Dec 29, 2006·Small·Dmitry G ShchukinYuri M Lvov
Aug 7, 2007·European Journal of Pharmacology·Roser FranciscoSantiago Ambrosio
Aug 9, 2008·International Journal of Nanomedicine·Wim H De Jong, Paul J A Borm
Oct 7, 2010·Nutrition and Cancer·Vaishali B PatelAdhip P N Majumdar
Oct 13, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Helvia W Casullo de AraújoGalba M Campos Takaki
Oct 17, 2012·International Journal of Pharmaceutical Investigation·Gaurav TiwariSaurabh K Bannerjee
Jan 8, 2013·Chemical Communications : Chem Comm·Svetlana A KonnovaRawil F Fakhrullin
Apr 23, 2013·Journal of Applied Toxicology : JAT·Xianyin LaiFrank A Witzmann
Feb 25, 2014·Applied Microbiology and Biotechnology·Nada StankovicJasmina Nikodinovic-Runic
May 2, 2014·Applied Biochemistry and Biotechnology·Rahul K SuryawanshiSatish V Patil
May 16, 2015·Scientific Reports·Maria R DzamukovaRawil F Fakhrullin
Sep 8, 2015·Journal of Food Science and Technology·N Darshan, H K Manonmani
Mar 6, 2016·The Kaohsiung Journal of Medical Sciences·Zu-Yau LinWan-Long Chuang
Mar 15, 2016·Nanoscale·Ekaterina A NaumenkoRawil F Fakhrullin
Jun 11, 2017·Journal of Pharmaceutical Sciences·Raghuvara YendluriRawil Fakhrullin
Jan 4, 2018·International Journal of Nanomedicine·Kai LiRong Wan
Jul 11, 2018·International Journal of Molecular Sciences·Priyanka SinghIvan Mijakovic
Aug 3, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yongze LiuXiao Yun Qian
Nov 2, 2018·International Journal of Molecular Sciences·Claudia KohoutLaura Polito
Feb 23, 2019·Materials·Joanna Dulińska-LitewkaAnna Karewicz
Mar 7, 2019·International Journal of Biological Macromolecules·Selin S SunerNurettin Sahiner
Apr 12, 2019·Journal of Colloid and Interface Science·Lorenzo LisuzzoGiuseppe Lazzara
May 12, 2019·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Shuangbin JiYuepu Pu
Jun 11, 2019·ACS Applied Materials & Interfaces·Gölnur FakhrullinaRawil Fakhrullin
Sep 21, 2019·Future Medicinal Chemistry·Giuseppe CirilloSilke Hampel
Sep 27, 2019·Biotechnology Journal·Ekaterina Naumenko, Rawil Fakhrullin
Nov 7, 2019·International Journal of Molecular Sciences·Kai ZhaoXiujun Fan

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Citations

Aug 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Svetlana BatashevaRawil Fakhrullin
Feb 12, 2021·The Science of the Total Environment·Rawil FakhrullinGölnur Fakhrullina
Feb 18, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Francesca PersanoRawil Fakhrullin
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Elvira RozhinaRawil Fakhrullin
Apr 6, 2021·Advances in Colloid and Interface Science·Irina PereiraAna Cláudia Paiva-Santos

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Methods Mentioned

BETA
infrared spectroscopy
Fluorescence
Assay
electrophoresis
confocal microscopy
fluorescence microscopy
AFM

Software Mentioned

GIMP
Comet Score
ENVI
Nanoscope Analysis
CytoViva
- MTI
Dage

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