PMID: 3755346Jun 1, 1986Paper

Selective cytotoxic lesions of the hippocampal formation and DRL performance in rats

Behavioral Neuroscience
J D SindenL E Jarrard

Abstract

Rats were given injections of ibotenic acid that made lesions of neurons throughout the hippocampus (CHC), or restricted to area CA3 (CA3), or to the subiculum (SUB), and were trained to lever press on a differential reinforcement of low rates (DRL) schedule. Their performance efficiency was compared with that of sham-operated (SO) rats in three experiments. Acquisition of DRL 12 s was only slightly impaired by any of the lesions. Increasing the DRL requirement to 18 s did not affect asymptotic efficiency of responding in the SO, CA3, or SUB group but markedly reduced efficiency in the CHC group. Administration of scopolamine reduced efficiency to the same extent in rats in all surgical treatment groups. It is concluded that hippocampal lesions made with ibotenic acid resemble conventional hippocampal lesions in their behavioral effects on DRL performance; that the behavioral effects of scopolamine administration do not appear to depend on disruption of activity of cholinoceptive cells in the hippocampal formation; and that DRL schedules, although highly sensitive to septohippocampal system disruption, discriminate more between the extent than the location of lesions in the system.

Citations

Jul 1, 1993·Behavioral and Neural Biology·L E Jarrard
May 3, 2005·Behavioural Brain Research·Valéria Catelli Infantozzi CostaGilberto Fernando Xavier
Aug 26, 1999·Life Sciences·R E Hampson, S A Deadwyler
Oct 1, 1997·Physiology & Behavior·B D YoungbloodR B Harris

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.