PMID: 2509530Nov 1, 1989Paper

Selective decrease in lysis of old thrombi after rapid administration of tissue-type plasminogen activator

Journal of the American College of Cardiology
K KanamasaW Ganz

Abstract

The safety of thrombolytic therapy of acute myocardial infarction could be improved if a method were developed to dissolve fresh occlusive coronary thrombus without simultaneously dissolving hemostatic thrombi outside the coronary arteries. This study is based on the assumption that, in a patient with evolving acute myocardial infarction, hemostatic thrombi are likely to be older than the thrombus responsible for occlusion of the coronary artery. It explored whether the relative rates of lysis of fresh and old thrombi could be influenced by the rapidity of recombinant tissue-type plasminogen activator (rt-PA) administration. In each of 17 dogs, two 1 h and two 24 h old thrombi were produced by inserting copper coils into both jugular and both femoral veins. After 24 h and 1 h, respectively, the coils with the thrombi were removed, weighed and inserted into the adjacent carotid and femoral arteries. A 1 mg/kg body weight dose of rt-PA was given either over 180 or over 30 min. The coils were removed and weights of the residual thrombi determined at the end of the 180 min infusion (Group I), at the end of the 30 min infusion (Group IIA) and 45 min after the 30 min infusion (Group IIB). The 24 h old thrombi were lysed significantly...Continue Reading

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Citations

Apr 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M A YenariG K Steinberg
Dec 4, 1992·Annals of the New York Academy of Sciences·E Falk
Oct 3, 1998·Intensive Care Medicine·N CurzenA Timmis
Sep 3, 1991·The American Journal of Cardiology·E Falk
Apr 1, 1992·Chest·G Agnelli, P Parise
Aug 30, 2005·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Kenneth R TurleyRashmi U Kothari

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