PMID: 2512037Mar 1, 1989Paper

Selective defect in gonadotrophin secretion in patients with autonomic failure

Clinical Endocrinology
T D WilliamsR Bannister

Abstract

We studied the neuroendocrine effects of a condition associated with abnormal hypothalamic amines. Hypothalamo-anterior pituitary function was assessed in five male subjects with autonomic failure (AF) and in five age and sex-matched controls. All subjects showed normal gonadotrophin and TSH responses to GnRH and TRH, respectively. In control subjects, intravenous infusion of naloxone caused a significant rise in overall LH concentrations as well as increased frequency and amplitude of LH pulses. In contrast, in AF subjects naloxone did not alter LH concentrations or increase LH pulse frequency. Naloxone also caused an increase in neurosecretory GH pulses not only in AF subjects but also in the controls. These results suggest that in man, ascending catecholamine pathways are important in the control of gonadotrophin secretion. The markedly different response of GH to an opioid antagonist in elderly subjects should be further investigated.

References

Mar 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·T D WilliamsR Bannister
Aug 20, 1984·The Journal of Comparative Neurology·V Chan-PalayS L Palay
Feb 1, 1980·The Journal of Clinical Endocrinology and Metabolism·J E MorleyA A Varner
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Feb 1, 1983·The American Journal of Medicine·R L ZerbeG L Robertson
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Citations

Dec 10, 1999·Movement Disorders : Official Journal of the Movement Disorder Society·J KimberC J Mathias
Jan 1, 1994·Surgical and Radiologic Anatomy : SRA·M F Sargon, H H Celik
Jan 1, 1994·Surgical and Radiologic Anatomy : SRA·D SzolarF Ebner
Jan 1, 1995·Surgical and Radiologic Anatomy : SRA·M M Reidenbach
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Dec 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ronald B George, Jason Hackett
Oct 1, 1996·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K AoyamaA Shigematsu
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Apr 11, 2001·Journal of the Peripheral Nervous System : JPNS·J Folan-Curran, F J Cooke
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Jan 1, 1995·International Orthopaedics·M F StancićA Stosić
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Feb 21, 2009·Okajimas Folia Anatomica Japonica·Naohiro Sonoda, Yuichi Tamatsu
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Jun 21, 2011·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·R Shane TubbsAaron A Cohen-Gadol
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·B Dudás, I Merchenthaler
Jun 24, 2017·Frontiers in Endocrinology·Bodil Ohlsson

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