Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation

Immunity
J H WangK Georgopoulos

Abstract

Mice homozygous for an Ikaros null mutation display distinct defects in the development of fetal and adult lymphocytes. Fetal T lymphocytes, and fetal and adult B lymphocytes and their earliest progenitors are absent. Postnatally, hematopoietic stem cells give rise to thymocyte precursors that undergo aberrant differentiation into the CD4 lineage and clonal expansion. The lack of NK cells and some gamma delta T cell subsets and a large reduction in thymic dendritic APCs suggest that Ikaros is essential for establishing early branch points in the postnatal T cell pathway. The lymphoid defects detected in Ikaros null mice reveal critical molecular differences between fetal and postnatal hematopoietic progenitors that dictate their ability to give rise to T cells. These studies also establish Ikaros as a tumor suppressor gene acting during thymocyte differentiation. Phenotypic comparison of this null mutation with a severe dominant-negative Ikaros mutation identifies molecular redundancy in the postnatal hemolymphoid system.

Citations

Aug 26, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·E V RothenbergM K Anderson
Dec 19, 2001·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C E WillettL A Steiner
Mar 17, 2004·Current Opinion in Immunology·Warren S PearPaul L Stein
Feb 13, 2004·Gene·Boris Bartholdy, Patrick Matthias
Nov 5, 2003·Trends in Immunology·David LibergMatthias Merkenschlager
Mar 2, 2005·Seminars in Immunology·Pierangela Sabbattini, Niall Dillon
Jun 21, 2002·Developmental and Comparative Immunology·Najia BoudarraJean-Pol Frippiat
Aug 13, 1998·Developmental and Comparative Immunology·A L Medvinsky, E A Dzierzak
Mar 6, 2003·Molecular Immunology·Lena StrömEva Severinson
Jul 1, 1997·Immunology Today·C Ardavín
Jun 1, 1997·Immunology Today·H von Boehmer
Nov 7, 2000·Experimental Hematology·H NakayamaM Harada
Jul 11, 1998·Biochimica Et Biophysica Acta·M A FarrarK Sauer
Mar 1, 2002·Current Opinion in Immunology·Kam-Wing Ling, Elaine Dzierzak
Jun 1, 1997·Current Opinion in Immunology·E O Long, N Wagtmann
Apr 1, 1997·Current Opinion in Immunology·K Georgopoulos
May 29, 1998·Current Opinion in Immunology·T Reya, R Grosschedl
May 29, 1998·Current Opinion in Immunology·H Clevers, P Ferrier
Mar 14, 2000·Current Opinion in Immunology·M BusslingerA G Rolink
Nov 30, 2002·Seminars in Immunology·Rebecca H Lian, Vinay Kumar
Dec 12, 2001·Trends in Immunology·C ArdavínH Hernández
Jul 26, 2013·Expert Reviews in Molecular Medicine·Wang-Dong XuDong-Qing Ye
Oct 9, 2002·Immunological Reviews·Ellen V Rothenberg, Christopher J Dionne
Oct 9, 2002·Immunological Reviews·Paul W KincadeMaria Isabel D Rossi
Nov 26, 2002·Immunological Reviews·Tom CupedoReina E Mebius
Mar 27, 2001·Nature Reviews. Genetics·S H Orkin
Jan 22, 2013·Nature Genetics·Linda HolmfeldtCharles G Mullighan
Sep 10, 2013·Nature Immunology·Hilde SchjervenStephen T Smale
Sep 21, 2013·Nature Immunology·Fotini Gounari, Barbara L Kee
Mar 22, 2006·Nature Immunology·Stephen T Smale, Kenneth Dorshkind
Sep 22, 2010·Nature Immunology·James P Di Santo
Mar 7, 2006·Nature Immunology·Toshimi YoshidaKatia Georgopoulos
Apr 2, 2004·Nature Reviews. Immunology·C Clare Blackburn, Nancy R Manley

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