Selective development of tolerance to beta-adrenoceptor agonists in skeletal muscle as compared with airway smooth muscle from the guinea-pig

Clinical and Experimental Pharmacology & Physiology
E HolmbergB Waldeck


1. Guinea-pig were fed with a diet containing terbutaline or placebo for 4--5 days. The trachea, soleus muscle and the extensor digitorum longus (EDL) from these animals were prepared for recording of isometric contractions in vitro. 2. After treatment with terbutaline in vivo, the response of the pilocarpine-contracted trachea to terbutaline and isoprenaline was slightly suppressed with no change in maximum relaxation. 3. After treatment with terbutaline in vivo the maximum depression of the incomplete tetanic contractions of the soleus muscle brought about by terbutaline or isoprenaline was diminished by about 70%. The response of the EDL was also attenuated after previous treatment with terbutaline in vivo. 4. These data indicate a selective development of tolerance to the effects of beta-adrenoceptor agonists in skeletal muscle as compared with tracheal smooth muscle. 5. The present results provide an experimental analogue to the clinical observation that patients being treated with beta-adrenoceptor agonists become tolerant to the tremorogenic rather than to the bronchodilating effect.


Apr 7, 1977·European Journal of Pharmacology·J S DouglasA Bouhuys
Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Dec 1, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·E Holmberg, B Waldeck
Jan 1, 1978·Journal of Supramolecular Structure·R J LefkowitzM Wessels
Feb 1, 1977·The Journal of Allergy and Clinical Immunology·S LarssonG Thiringer
Jan 1, 1979·General Pharmacology·J VallièresL Bukowiecki
Apr 1, 1975·British Journal of Clinical Pharmacology·G E MarlinP Turner
Mar 1, 1976·British Journal of Pharmacology·A A Anderson, G M Lees


Mar 16, 1984·European Journal of Pharmacology·M J Ward, D R Tomlinson
Jul 1, 1992·Pharmacology & Toxicology·A BergendalC G Löfdahl
Jun 1, 1985·Acta Physiologica Scandinavica·H Hallberg, O Almgren
Jan 1, 1986·Acta Pharmacologica Et Toxicologica·K E Andersson
Jul 1, 1986·Medical Toxicology·K M LulichJ W Paterson

Related Concepts

Adrenergic beta-Agonists
Airway Resistance
Drug Tolerance
Cavia porcellus
Smooth Muscle
Tissue Specificity

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