Selective differences among translation termination codons

Gene
P M Sharp, M Bulmer

Abstract

The frequency of use of the three alternative translation termination codons has been examined in 165 Escherichia coli, 52 Bacillus subtilis and 106 Saccharomyces cerevisiae genes. Genes were first categorised according to their degree of bias in sense codon usage. In each species there is a very strong bias in favour of UAA (over UAG and UGA) in genes where sense codon usage is highly biased. This bias declines, principally with an increase in the use of UGA, in genes with lower sense codon bias. It appears that selection operating during translation may maintain the bias in stop codon usage. Such selection could result from the greater availability of UAA-cognate release factor(s), or from a lower frequency of translational readthrough at UAA.

References

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Citations

Aug 1, 1992·Antonie van Leeuwenhoek·P Linder
May 1, 1996·Journal of Molecular Evolution·S G Andersson, P M Sharp
Nov 30, 1993·Gene·M MalumbresJ F Martín
May 31, 2002·Gene·Russell J Grocock, P M Sharp
Oct 6, 1999·Current Opinion in Microbiology·I MoszerA Danchin
Jan 6, 2007·Journal of Proteome Research·William E RunningJames P Reilly
Apr 25, 1990·Nucleic Acids Research·C M BrownW P Tate
Jul 1, 1993·Nucleic Acids Research·C M BrownW P Tate
Dec 6, 2003·Genome Research·Gila Lithwick, Hanah Margalit
Sep 15, 2012·Biology Direct·Inna S PovolotskayaPeter K Vlasov
Oct 1, 1991·Yeast·P M Sharp, E Cowe
Aug 19, 2008·Journal of Theoretical Biology·Jacques M Bahi, Christian J Michel
Oct 21, 1992·Journal of Theoretical Biology·G S Mani
Jun 19, 2015·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Tit-Yee Wong, Steve D Schwartzbach
Jun 15, 2016·Molecular Biology and Evolution·Yulong WeiXuhua Xia
Sep 14, 2014·The Journal of Biological Chemistry·Gürkan KorkmazSuparna Sanyal

Related Concepts

Natto Bacteria
Sense Codon
Alkalescens-Dispar Group
Genes, Bacterial
Genes, Fungal
Genes, Regulator
Poly(A) Tail
Saccharomyces cerevisiae
Terminator Regions, Genetic
Protein Biosynthesis

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