Selective Direct Toxicity of Cocaine on Fetal Mouse Neurons: Teratogenic Implications of Neurite and Apoptotic Neuronal Loss

Annals of the New York Academy of Sciences
Marie-Cécile NassogneP J Courtoy

Abstract

This chapter reviews epidemiologic clinical surveys and experimental animal studies, indicating that cocaine may induce severe teratogenic effects on the developing brain. Evidence for direct toxic effects is next presented. Using cocultures of embryonic brain cells, we demonstrate that cocaine selectively affects neuronal cells, first causing a dramatic reduction in the number and length of neurites, then extensive neuronal death by apoptosis. By contrast, cocaine affected neither the abundance of astroglial cells nor their glial fibrillary acidic protein content. These effects are not due to cocaine metabolites. The contributions of indirect and direct effects that could account for cocaine neuroteratogenicity are finally discussed.

References

Jun 8, 1992·Neuroscience Letters·P GressensP Evrard
Apr 1, 1992·Journal of Developmental and Behavioral Pediatrics : JDBP·J M Struthers, R L Hansen
Jul 1, 1991·Neurotoxicology and Teratology·G A Richardson, N L Day
Oct 1, 1991·American Journal of Obstetrics and Gynecology·S K GeorgeP Preston
Jul 1, 1991·Teratology·R P KapurT H Shepard
Sep 1, 1990·Anesthesiology·J A FlemingP G Barash
Jan 1, 1990·Annals of the New York Academy of Sciences·P M Whitaker-AzmitiaE C Azmitia
Jan 1, 1989·Annals of the New York Academy of Sciences·J R WoodsR K Miller
Mar 23, 1989·The New England Journal of Medicine·B ZuckermanL E Fried
Jul 1, 1987·Neurotoxicology and Teratology·I J ChasnoffW J Burns
Oct 1, 1986·American Journal of Obstetrics and Gynecology·T R MooreR Resnik
Mar 1, 1986·The Journal of Pediatrics·I J ChasnoffC M Stack
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·M C NassogneP J Courtoy
Jan 1, 1994·The American Journal of Orthopsychiatry·D Scherling
Jan 2, 1995·The Journal of Comparative Neurology·B E KosofskyS E Hyman
Aug 1, 1995·Pharmacology, Biochemistry, and Behavior·K ShimosatoT Saito
Jan 1, 1994·Epidemiologic Reviews·C Holzman, N Paneth
Sep 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J M Martinez CrespoA Fortuny
Jan 1, 1995·American Journal of Obstetrics and Gynecology·J M MillerF A Regan
Jan 2, 1995·The Journal of Comparative Neurology·B E KosofskyS E Hyman
Jul 1, 1994·Journal of Computer Assisted Tomography·B Gomez-Anson, R G Ramsey
Mar 1, 1994·The Journal of Clinical Investigation·D ZachorI Ocrant
Sep 1, 1993·Pediatric Research·D E Weese-MayerP M Carvey
Nov 9, 1993·European Journal of Pharmacology·M L Albuquerque, C D Kurth
Jun 8, 1993·Brain Research. Developmental Brain Research·D J Burchfield, R M Abrams
Mar 1, 1993·Clinical Pharmacology and Therapeutics·S SchenkerT S King
Jan 1, 1995·International Review of Cytology·E J Sanders, M A Wride
Aug 1, 1995·Journal of Pharmacological and Toxicological Methods·A MalekD R Mattison
Sep 25, 1995·The Journal of Comparative Neurology·M S Lidow, P Rakic
Feb 15, 1996·European Journal of Biochemistry·A J HaleG T Williams
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L Vaux, A Strasser
Jan 1, 1996·Journal of Child Neurology·C H TsayD M Ferriero
Jan 1, 1996·Reproduction, Fertility, and Development·D J BurchfieldD Phillips
Oct 1, 1996·The Journal of Pediatrics·S W JacobsonL M Chiodo

❮ Previous
Next ❯

Citations

Jun 19, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emily J RossGregg D Stanwood
Feb 25, 2003·Anesthesia and Analgesia·Emmanuel BoselliJacques Portoukalian
Oct 7, 2006·Current Opinion in Anaesthesiology·Alain Borgeat, Stephan Blumenthal
Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·D A ZachorA K Percy
Nov 8, 2002·Pediatric Pulmonology·Fanny AutretJorge Gallego
Jan 26, 2007·Journal of Neurochemistry·Teresa Cunha-OliveiraCatarina Resende Oliveira
Sep 8, 2005·Southern Medical Journal·Steven B Karch
Aug 22, 2015·BioMed Research International·Lucilia B LepschCritoforo Scavone

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.