Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10

The Journal of Immunology : Official Journal of the American Association of Immunologists
Gustavo Batista MenezesPaul Kubes

Abstract

Hepatic neutrophil adhesion during endotoxemia is an integrin-independent, CD44-dependent process. Because integrins function in other endotoxemic vasculatures, we used spinning disk confocal intravital microscopy to assess whether LPS down-modulated integrin functions in sinusoids. First, we applied fMLP onto the liver surface, and compared it with systemic LPS administration. Local fMLP caused neutrophil adhesion, crawling, and emigration for at least 2 h. Surprisingly, the number of adherent and crawling neutrophils was markedly reduced in Mac-1(-/-) and ICAM-1(-/-) mice, but not in mice treated with anti-CD44 mAb. By contrast, systemic LPS injection induced a robust accumulation of neutrophils in sinusoids, which was dependent on CD44, but not on integrins. Strikingly, local fMLP could not induce any integrin-dependent adhesion in endotoxemic mice treated with anti-CD44 mAb, indicating that Mac-1-dependent neutrophil adhesion was inhibited by LPS. This response was localized to the hepatic microvasculature because neutrophils still adhered via integrins in brain microvasculature. ICAM-1/ICAM-2 levels were not decreased, but following LPS treatment, Mac-1 was down-regulated in neutrophils localized to liver, but not in the c...Continue Reading

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Citations

Mar 13, 2012·Immunologic Research·Jackson LiangYao Li, Lai Guan Ng
Sep 21, 2013·Nature Immunology·Craig N Jenne, Paul Kubes
Nov 9, 2011·Nature Medicine·Mia Phillipson, Paul Kubes
Apr 2, 2011·The Journal of Biological Chemistry·Claude A PiantadosiHagir B Suliman
Aug 18, 2010·The Journal of Clinical Investigation·Edward KerschenHartmut Weiler
Feb 26, 2011·Critical Care : the Official Journal of the Critical Care Forum·Heitor A Paula Neto, Paul Kubes
Mar 6, 2015·Frontiers in Immunology·Braedon McDonald, Paul Kubes
May 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pedro Elias MarquesGustavo Batista Menezes
Mar 16, 2017·European Journal of Immunology·Rafael S CzepielewskiCristina Bonorino
Nov 23, 2011·Toxicologic Pathology·Braedon McDonald, Paul Kubes
Jan 13, 2018·Annual Review of Immunology·Paul Kubes, Craig Jenne
Dec 29, 2017·Molecular Biology of the Cell·Ning LiMian Long
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes
Apr 20, 2019·European Journal of Immunology·Mokarram Hossain, Paul Kubes
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Sep 19, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Thiago Henrique Caldeira de OliveiraMauro Martins M Teixeira
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Sep 7, 2019·Journal of Veterinary Pharmacology and Therapeutics·Haifeng YangYiyi Hu
Feb 14, 2019·Physiological Reviews·Pei Xiong Liew, Paul Kubes
Oct 17, 2019·Frontiers in Immunology·Matthias Bartneck, Jing Wang
Sep 19, 2015·World Journal of Clinical Cases·Jia-Ren LiuKoichi Yuki
Nov 12, 2017·Cell and Tissue Research·Débora Moreira AlvarengaGustavo Batista Menezes
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Jun 24, 2017·Journal of Leukocyte Biology·Young-Min Hyun, Chang-Won Hong
May 10, 2019·Frontiers in Immunology·Chris John WestonDavid H Adams
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Sep 18, 2012·Gastroenterology·Paul Kubes, Wajahat Z Mehal
Jan 14, 2017·Microbiology Spectrum·Justin F Deniset, Paul Kubes

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