Selective downregulation of rhesus macaque and sooty mangabey major histocompatibility complex class I molecules by Nef alleles of simian immunodeficiency virus and human immunodeficiency virus type 2

Journal of Virology
M Quinn DeGottardiDavid T Evans

Abstract

Human immunodeficiency virus type 1 (HIV-1) Nef downregulates HLA-A and -B molecules, but not HLA-C or -E molecules, based on amino acid differences in their cytoplasmic domains to simultaneously evade cytotoxic T lymphocyte (CTL) and natural killer cell surveillance. Rhesus macaques and sooty mangabeys express orthologues of HLA-A, -B, and -E, but not HLA-C, and many of these molecules have unique amino acid differences in their cytoplasmic tails. We found that these differences also resulted in differential downregulation by primary simian immunodeficiency virus (SIV) SIV(smm/mac) and HIV-2 Nef alleles. Thus, selective major histocompatibility complex class I downregulation is a conserved mechanism of immune evasion for pathogenic SIV infection of rhesus macaques and nonpathogenic SIV infection of sooty mangabeys.

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Citations

May 14, 2010·Journal of Virology·Anke SpechtFrank Kirchhoff
Oct 21, 2011·Journal of Virology·Anke HeigeleFrank Kirchhoff
May 2, 2008·Biochemical and Biophysical Research Communications·C V SanthoshRobin Mukhopadhyaya
May 14, 2016·Cell Host & Microbe·Richard AppsMary Carrington
Feb 11, 2015·Journal of Theoretical Biology·Hilla Behar, Yoram Louzoun
Nov 19, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helen L WuJonah B Sacha
Sep 21, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Priyankana BanerjeeDavid T Evans
Nov 8, 2019·American Journal of Respiratory Cell and Molecular Biology·Marco Pio La MannaNadia Caccamo

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