Selective drug delivery approaches to lesioned brain through blood brain barrier disruption

Expert Opinion on Drug Delivery
Zahraa S Al-Ahmady

Abstract

The development of therapeutics for central nervous system (CNS) disorders is still considered a challenging area in drug development due to insufficient translocation through the blood-brain barrier (BBB). Under normal conditions, BBB restrict the penetration of more than 98% of blood-borne molecules including drugs to the CNS. However, recent research findings have proven that the nature of the BBB is altered in several neurological conditions. This complexity encourages revisiting drug delivery strategies to the CNS as this can give a wide range of opportunities for CNS drug development. This review focuses on nanotechnology-based drug delivery platforms designed for selective recruitment into the lesioned brain by taking advantages of BBB disruption that is associated with certain neurological conditions. Current CNS therapeutic strategies do not fully address the pathophysiological adaptation of BBB in their design. The lack of selective delivery to the brain lesions has been the culprit behind the failure of many CNS therapeutics. This highlighted the need for smart designs of advanced drug delivery systems that take advantage of BBB structural changes in CNS diseases. Recently, promising examples have been reported in th...Continue Reading

References

Aug 5, 1975·Biochimica Et Biophysica Acta·W M Pardridge, W H Oldendorf
Feb 1, 1976·The Journal of Physiology·H Davson
Sep 1, 1992·Stroke; a Journal of Cerebral Circulation·P M Kochanek, J M Hallenbeck
Oct 1, 1991·The Journal of Antimicrobial Chemotherapy·R T ProffittJ P Adler-Moore
Jul 1, 1990·Brain Research. Molecular Brain Research·G T CokerK L O'Malley
Sep 1, 1990·Stroke; a Journal of Cerebral Circulation·S ImaizumiP H Chan
Dec 1, 1986·Radiology·R I GrossmanD H Silberberg
Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Jun 19, 1995·Brain Research·S SkarlatosW M Pardridge
Dec 1, 1994·The Journal of Pharmacy and Pharmacology·M FrestaA Russo
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·S K HobbsR K Jain
Mar 10, 2001·Journal of Neurochemistry·Y Zhang, W M Pardridge
Mar 10, 2001·Journal of Neuroimmunology·Y Zhang, W M Pardridge
Apr 5, 2001·Trends in Molecular Medicine·H LassmannC Lucchinetti
May 2, 2001·The Journal of Cell Biology·M HellströmC Betsholtz
Jan 18, 2002·Journal of Neurochemistry·Rao Muralikrishna AdibhatlaR J Dempsey
Jan 18, 2003·Vascular Pharmacology·Michel DemeuleRichard Béliveau
Dec 11, 2003·Multiple Sclerosis : Clinical and Laboratory Research·Alireza Minagar, J Steven Alexander
Dec 25, 2003·Cerebrovascular Diseases·Nils Gunnar Wahlgren, Niaz Ahmed
May 14, 2004·Journal of Neurochemistry·Berislav V Zlokovic
Jul 13, 2004·Experimental Neurology·L HoyteA M Buchan
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Apr 6, 2005·Trends in Neurosciences·Berislav V Zlokovic
Oct 12, 2005·Neurology·B BielekovaH F McFarland
Mar 3, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Sam C S Au-YeungK Wayne Riggs
Aug 29, 2006·Surgical Neurology·Judy HuangRafael J Tamargo
Nov 25, 2006·Brain : a Journal of Neurology·E A van VlietJ A Gorter
Sep 19, 2007·Critical Care : the Official Journal of the Critical Care Forum·Ramez Reda Moustafa, Jean-Claude Baron

❮ Previous
Next ❯

Citations

Feb 25, 2020·Current Pharmaceutical Design·Yoichi Morofuji, Shinsuke Nakagawa
Jun 18, 2020·Pharmaceutics·Maria Inês TeixeiraDimitrios A Lamprou
Jun 28, 2019·International Journal of Molecular Sciences·Rana Abdul RazzakFrank J Gunn-Moore
Nov 18, 2020·Pharmaceutics·Huilong Luo, Eric V Shusta
Jul 20, 2019·Brain Research Bulletin·Gisele E BruchAndré R Massensini
May 28, 2020·Journal of Medicinal Chemistry·Pauline ZipfelPatrick Dallemagne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.