Selective effect of levocabastine on histamine receptor and histamine release from human leukocytes and guinea pig isolated tissue

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
I M GarreldsF J Zijlstra

Abstract

Levocabastine is a potent histamine H1 receptor antagonist used topically in the treatment of patients with allergic rhinitis. It has been suggested that antihistamines also have anti-inflammatory properties. The present study was performed to investigate whether levocabastine, in addition to the anti-H1 receptor activity, has anti-inflammatory properties and thus is able to modulate the release of histamine and cytokines, such as interleukin 5 from human leukocytes and isolated tissues. Leukocytes suspensions were prepared by dextran sedimentation of peripheral venous blood drawn from allergic and healthy volunteers. Leukocytes obtained from allergic volunteers were preincubated for 30 minutes with levocabastine (doses 10(-8) M to 10(-6) M) and thereafter incubated with allergen. Leukocytes obtained from healthy volunteers were incubated for zero to three hours with levocabastine (doses 10(-14) M to 10(-3) M). Histamine release was measured by an automated fluorometric method. Interleukin-5 release was measured by enzyme linked immunoassay. Contractile responses to histamine on guinea pig trachea and lung parenchyma as well as the release of histamine and interleukin-5 by the tissues were investigated in the absence or presenc...Continue Reading

References

May 1, 1991·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P H Van de HeyningM Rosseel
Nov 1, 1991·Clinical Pharmacokinetics·F E Simons, K J Simons
Jul 1, 1990·The American Review of Respiratory Disease·R M NaclerioD Proud
Feb 1, 1986·The Journal of Allergy and Clinical Immunology·S T HolgateP H Howarth
Nov 1, 1988·The Journal of Allergy and Clinical Immunology·J BousquetF B Michel
Jun 1, 1989·British Journal of Pharmacology·P T Peachell, F L Pearce
Sep 1, 1989·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M NabeR G Townley
Oct 1, 1986·The Journal of Allergy and Clinical Immunology·E GomezR J Davies
Apr 1, 1987·Journal of Pharmacological Methods·J C de JongsteK F Kerrebijn
Sep 1, 1982·The Journal of Allergy and Clinical Immunology·N Mygind
Aug 1, 1980·British Journal of Pharmacology·M K Church, C F Gradidge
Oct 1, 1984·The Journal of Allergy and Clinical Immunology·R P SchleimerL M Lichtenstein
Jan 1, 1993·International Archives of Allergy and Immunology·A L de WeckS Takafuji
May 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W A MasseyL M Lichtenstein
Mar 14, 1995·European Journal of Pharmacology·I M GarreldsF J Zijlstra
Sep 1, 1960·British Journal of Pharmacology and Chemotherapy·I MOTA, W da SILVA

❮ Previous
Next ❯

Citations

Aug 11, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Aude PaulyChristophe Baudouin
Mar 26, 1998·American Journal of Rhinology·R Gerth van Wijk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.