Selective effects of clofibrate on alkaline phosphatase isoenzymes in serum

Clinica Chimica Acta; International Journal of Clinical Chemistry
K B WhitakerD W Moss

Abstract

Administration of clofibrate to both hyperlipidaemic patients and normolipidaemic subjects produced a significant decrease, averaging 22%, in serum alkaline phosphatase activity. Quantitative isoenzyme analysis showed that this change was entirely attributable to an average reduction of 39% in the activity of liver alkaline phosphatase, and that no significant change in the bone isoenzyme occurred. An accompanying fall in serum gamma-glutamyltransferase activity was seen in some subjects but this change was not statistically significant in the group as a whole.

References

Jan 1, 1981·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A K Walli, D Seidel
Jan 5, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·A Ansari, F A Salem
Jan 1, 1983·Veterinary Clinical Pathology·W E HoffmannH Morris
Sep 7, 2007·Veterinary Clinical Pathology·Nicole J Fernandez, Beverly A Kidney

Citations

Apr 12, 1975·Lancet·J H Elwood, W Thompson
Apr 12, 1975·Lancet·R W SchadeA van T Laar
Jan 1, 1975·The Journal of Clinical Investigation·M A D'Costa, A Angel
Jul 14, 1977·The New England Journal of Medicine·C M Kunin
Sep 22, 1977·The New England Journal of Medicine·L R Krasno, D C Harrison
Aug 19, 1976·The New England Journal of Medicine·M L Janower
Feb 1, 1972·Journal of Clinical Pathology·C P PriceH G Sammons
Oct 1, 1963·Annals of Internal Medicine·L HELLMANR S ROSENFELD

Related Concepts

Gamma-glutamyl transferase
Alkaline Phosphatase
Lipidemias
Skeletal Bone
Athromidin
Liver
GGT1
Alloenzymes

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