PMID: 6406780Jun 20, 1983Paper

Selective effects of diltiazem, a benzothiazepine calcium channel blocker, and diazepam, and other benzodiazepines on the Na+/Ca2+ exchange carrier system of heart and brain mitochondria

Life Sciences
M A Matlib, A Schwartz

Abstract

Diltiazem, diazepam, and clonazepam effectively inhibit Na+-induced Ca2+ release from mitochondria isolated from rabbit heart and rat brain. At 10 mM NaCl, the 50% inhibition of the rate of Ca2+ release occurred at 5, 7, 40 and 350 microM of clonazepam d-cis-diltiazem, diazepam and 1-cis-diltiazem, respectively. Ro 15-1788 (imidazobenzodiazepine), a pharmacological antagonist presumably at the high affinity site of diazepam, had no effect either alone or in combination with diltiazem or diazepam. We suggest that the Na+/Ca2+ exchange carrier in mitochondria may be a common receptor for diltiazem and diazepam.

References

Aug 24, 1976·Biochemistry·J S PuskinP R Russell
May 1, 1979·Pharmacology, Biochemistry, and Behavior·R F SquiresB Beer
Nov 8, 1979·Biochimica Et Biophysica Acta·P A Bernard, R S Cockrell
Jul 15, 1975·Life Sciences·E CostaA Suria
Jan 1, 1977·Annual Review of Pharmacology and Toxicology·A Fleckenstein
Apr 18, 1978·Biochemistry·A ScarpaG Dubyak
Jan 22, 1971·Biochemical and Biophysical Research Communications·C L Moore
Aug 1, 1974·Journal of Molecular and Cellular Cardiology·E CarafoliC Kratzing
Apr 9, 1981·Nature·W HunkelerW Haefely
Feb 18, 1982·The American Journal of Cardiology·A Schwartz
Mar 1, 1980·Canadian Journal of Physiology and Pharmacology·J Church, T T Zsotér

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Citations

Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·G GreveL Stangeland
Jan 1, 1985·Canadian Anaesthetists' Society Journal·B A Britt
Jun 19, 2012·Pflügers Archiv : European journal of physiology·Paola PizzoTullio Pozzan
Jul 1, 1985·Biochemical Pharmacology·S TakeoM Sakanashi
Sep 10, 1985·European Journal of Pharmacology·W G NaylerM McKelvie
Nov 12, 1991·European Journal of Pharmacology·T MatsudaA Baba
Jan 1, 1991·The International Journal of Biochemistry·R Moreno-SánchezP K Chiang
Sep 1, 1986·Pharmacology, Biochemistry, and Behavior·N P Pillai, D H Ross
Nov 1, 1993·Trends in Pharmacological Sciences·D A Cox, M A Matlib
Nov 23, 2012·ACS Chemical Neuroscience·José-Carlos Fernández-MoralesAntonio G García
Jan 24, 2009·Biochimica Et Biophysica Acta·Nicolas DemaurexMaud Frieden
Dec 1, 1986·Journal of Neurochemistry·C A CarvalhoA P Carvalho
Jan 13, 2005·Canadian Journal of Physiology and Pharmacology·Satoshi Takeo, Kouichi Tanonaka
Aug 16, 1984·Biochemical and Biophysical Research Communications·K B WalshA Schwartz
Jul 1, 1989·Toxicology and Applied Pharmacology·D J MinnemaR D Greenland
Jul 28, 2018·Frontiers in Cellular Neuroscience·Anna RonowskaAgnieszka Jankowska-Kulawy
Sep 1, 1988·The American Journal of Physiology·M A Matlib
Apr 1, 1986·Cell Calcium·J S KaradjovV P Zinchenko
Jul 1, 1986·Toxicology and Applied Pharmacology·J D JohnsonG E Isom
Apr 14, 2010·Biochimica Et Biophysica Acta·Ernesto Carafoli

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