Abstract
The rapid and direct effects of nitric oxide (NO) donors sodium nitroprusside (SNP) and isosorbide dinitrate (ISDN) on the hepatic and biliary disposition of chlorzoxazone (CZX), a marker of CYP2E1, and dextromethorphan (DEM), a marker of CYP2D1, were studied in a single-pass isolated perfused rat liver model. Livers (n = 30) were perfused with constant concentrations of NO donors (0-120 min) in addition to infusion of CZX or DEM (60-120 min), and periodical outlet and bile samples were collected. Both ISDN and SNP significantly reduced (30 and 60%, respectively) the hepatic extraction ratio of CZX and decreased (50 and 70%, respectively) the recovery of the CYP2E1-mediated metabolite, 6-hydroxychlorzoxazone, in the outlet perfusate and bile. As for DEM, both NO donors increased (up to 3.5-fold) the recovery of the CYP2D1-mediated metabolite dextrorphan (DOR) in the outlet perfusate. However, this was associated with a simultaneous decrease (50-75%) in the excretion of the metabolite into the bile, thus resulting in no change in the overall recovery of DOR as a result of NO donor treatment. The decrease in the biliary excretion of DOR was caused by NO-induced simultaneous reductions in both the conjugation of DOR and biliary cl...Continue Reading
References
Dec 1, 1977·Journal of Pharmacokinetics and Biopharmaceutics·K S Pang, M Rowland
Jan 1, 1990·Clinical and Experimental Pharmacology & Physiology·W T Abed
Nov 1, 1990·Chemical Research in Toxicology·R PeterC S Yang
Dec 1, 1986·Infection and Immunity·P GhezziC A Dinarello
Aug 7, 1981·Journal of Chromatography·D M BaaskeJ E Carter
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·O G KhatsenkoJ R Vane
Jan 1, 1993·Archives of Biochemistry and Biophysics·D A WinkR W Nims
Feb 24, 1993·Biochemical Pharmacology·N L KerryF Bochner
Jan 1, 1996·Life Sciences·L Chen, C S Yang
Aug 1, 1996·Journal of Pharmaceutical and Biomedical Analysis·A J KillardD P Bogan
Nov 15, 1996·Journal of Chromatography. B, Biomedical Applications·D P Bogan, R O'Kennedy
Jan 15, 1997·Archives of Biochemistry and Biophysics·D GergelA I Cederbaum
Apr 1, 1997·Biopharmaceutics & Drug Disposition·M H CourtD J Greenblatt
Jan 9, 1998·Drug Metabolism Reviews·E T Morgan
Aug 28, 1998·Naunyn-Schmiedeberg's Archives of Pharmacology·M Feelisch
Mar 28, 2002·Pharmacology & Therapeutics·K W Renton
Jun 20, 2002·Pharmacology & Toxicology·Yoshiaki KawashimaToshiyuki Someya
Nov 26, 2002·The Journal of Biological Chemistry·Mark J I PaineC Roland Wolf
Jan 4, 2003·Archives of Pharmacal Research·Im-Sook SongChang-Koo Shim
Mar 30, 1960·Annals of the New York Academy of Sciences·A H CONNEY, J J BURNS
Mar 25, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David S RiddickJohn Y L Chiang
Mar 31, 2004·The Journal of Pharmacology and Experimental Therapeutics·Ragini Vuppugalla, Reza Mehvar
Jun 8, 2004·Current Drug Metabolism·Kenneth W Renton
Sep 24, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ragini Vuppugalla, Reza Mehvar
Jan 22, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Spencer Ling, Fakhreddin Jamali
Mar 22, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ragini Vuppugalla, Reza Mehvar
Citations
Jun 28, 2011·Chemical Research in Toxicology·Antonia F StepanMichael D Aleo
Jul 26, 2011·Chemical Research in Toxicology·Kristine C OlsonPhilip Lazarus
Apr 26, 2012·Chemical Research in Toxicology·Slobodan Rendic, F Peter Guengerich
Jan 25, 2013·World Journal of Gastroenterology : WJG·Seok Ling OngAshley R Dennison
Sep 26, 2013·Pharmaceutical Research·Mohammad K MiahReza Mehvar
Jul 23, 2011·Journal of Pharmaceutical Sciences·Imam H Shaik, Reza Mehvar
Dec 25, 2009·The Journal of Surgical Research·Gianpiero GravanteAshley R Dennison
Mar 6, 2013·Chemico-biological Interactions·Xin TianHai-Ling Qiao
Jun 12, 2009·The Journal of Surgical Research·Gianpiero GravanteAshley R Dennison
Feb 13, 2010·Journal of Proteome Research·Yang ZhangYouhe Gao