PMID: 9421827Jan 9, 1998Paper

Selective effects on prefrontal cortex serotonin by dopamine D3 receptor agonism: interaction with low-dose haloperidol

Progress in Neuro-psychopharmacology & Biological Psychiatry
M R Lynch

Abstract

1. Negative symptoms of schizophrenia are characterized by amotivation, anhedonia and anergia. These aspects of the symptom profile can be modeled by D3 agonism in animal behavioral models. 2. Serotonergic systems have been implicated in pathophysiologic substrates for this disorder; most notably, in deficit state schizophrenia, as newer 'atypical' neuroleptics which are especially efficacious for treating this syndrome antagonize central 5-HT2 receptors. 3. FC regions may also be important in chronic negative symptoms, as hypofrontality has been associated with these schizophrenic features. 4. The author examined effects of a behaviorally-active dose of the D3 agonist, 7OH, on 5-HT metabolism in FC, and the ability of a low-dose neuroleptic treatment to antagonize this biochemical effect. 5. Acute administration of 7OH induced a selective decrease of 5-HT turnover in the FC without affecting metabolism of this transmitter in more subcortical DA regions. 6. Hal, which has previously been demonstrated to antagonize electrophysiologic, biochemical and behavioral effects of 7OH, was without effect on agonist-induced decreases in 5-HT turnover. 7. The biochemical association between D3 agonism and reductions of FC 5-HT may be signi...Continue Reading

References

Jan 1, 1976·Psychopharmacologia·W RuchH R Bürki
Feb 18, 1992·Biochemical Pharmacology·P SokoloffJ C Schwartz
May 1, 1992·Neurochemical Research·K Yoshimoto, W J McBride
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·T Kling-Petersen, K Svensson
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D LévesqueP Sokoloff
Jan 1, 1991·Journal of Neural Transmission. General Section·R C Arora, H Y Meltzer
Dec 17, 1991·European Journal of Pharmacology·C Gui-Hua, W L Woolverton
Apr 1, 1990·International Clinical Psychopharmacology·Y MizukiM Yamada
Aug 1, 1990·Biological Psychiatry·A E MerriamH M van Praag
Nov 3, 1987·Brain Research·J J SoghomonianL Descarries
Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·K SvenssonA Carlsson
Apr 1, 1988·Experimental Neurology·M DousseY Tran Dinh
Jan 1, 1986·European Archives of Psychiatry and Neurological Sciences·R J MathewS Tant
Feb 1, 1995·Journal of Clinical Psychopharmacology·R L Borison
Jul 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K D BurrisP B Molinoff
May 24, 1995·European Journal of Pharmacology·B LevantE B De Souza
Jan 5, 1995·European Journal of Pharmacology·A M Gonzalez, D R Sibley
Jan 1, 1994·Journal of Neural Transmission. General Section·K SvenssonN Waters
Oct 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·S J DuinkerkeH L Busard
Aug 11, 1994·European Journal of Pharmacology·M Hillefors-Berglund, G Von Euler
Jan 1, 1993·Journal of Neural Transmission. General Section·N WatersA Carlsson
Feb 15, 1994·Biological Psychiatry·S SzymanskiJ Lieberman
Nov 16, 1993·European Journal of Pharmacology·G DamsmaH Wikström
Dec 1, 1995·Trends in Pharmacological Sciences·G R SeabrookL J Bristow
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·D AcciliS Fuchs
Feb 1, 1996·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F P BymasterD T Wong

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Citations

Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roshan CoolsMark D'Esposito
Mar 17, 2007·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Shawn E ChristDesirée A White

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