PMID: 9521626May 16, 1998

Selective elevation of glutathione levels in target tissues with L-2-oxothiazolidine-4-carboxylate (OTC) protects against hyperoxia-induced lung damage in protein-energy malnourished rats: implications for a new treatment strategy

The Journal of Nutrition
M A LevyT M Bray

Abstract

It has become recognized that enhancing the antioxidant defense system during the early phase of rehabilitation is important to the survival of wasting protein-energy malnourished (PEM) patients. In this study, we compared the efficacy of dietary protein replenishment and supplementation with L-2-oxothiazolidine-4-carboxylate (OTC, 3.5 mg/d), a cysteine precursor, to protect against hyperoxia-induced lung damage in PEM rats. The PEM rats were produced by feeding weanling rats a protein-deficient diet (0.5% protein) for 14 d. PEM rats were then divided in three dietary treatment groups, 0.5% protein (-Pr), 0.5% protein plus the OTC supplement (+OTC), or 15% protein (+Pr) during 4 d of either hyperoxia (85% O2) or air exposure. Increased lung-to-body weight ratios, indicative of oxidative tissue damage, were observed following exposure to hyperoxia in -Pr and +Pr rats, but not in +OTC rats, even though the OTC supplement and the 15% protein diet contained a comparable amount of cysteine. Tissue reduced glutathione (GSH) status, GSH-dependent enzyme activity and antioxidant defense enzyme activities were monitored in the lung, liver and blood during 4 d of hyperoxia exposure. OTC supplementation enhanced GSH levels significantly i...Continue Reading

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Citations

May 10, 2000·The Journal of Nutrition·P J FrakerT L Vollmer
Nov 28, 2006·International Journal of Food Sciences and Nutrition·James B LothianLarry C Lands
Mar 11, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·J Wernerman, F Hammarqvist
Jul 2, 2003·Neurotoxicity Research·P G Paterson, B H Juurlink
Jul 25, 2007·Biological Trace Element Research·Olusegun Lateef Adebayo, Gbenga Adebola Adenuga

Related Concepts

2-oxothiazolidine-4-carboxylic acid, (S)-isomer
Dietary Proteins
Reduced Glutathione
Lung
Marasmus
Pyroglutamate
Thiazoles
Rats, Wistar
Hyperoxia
Thiazolidines

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