Selective endothelial dysfunction in conscious dogs after cardiopulmonary bypass

Journal of Applied Physiology
P ZanaboniD P Nyhan

Abstract

It has previously been demonstrated that cardiopulmonary bypass (CPB) causes prolonged pulmonary vascular hyperreactivity (D.P. Nyhan, J.M. Redmond, A.M. Gillinov, K. Nishiwaki, and P.A. Murray. J. Appl. Physiol. 77: 1584-1590, 1994). This study investigated the effects of CPB on endothelium-dependent (acetylcholine and bradykinin) and endothelium-independent (sodium nitroprusside) pulmonary vasodilation in conscious dogs. Continuous left pulmonary vascular pressure-flow (LP-Q) plots were generated in conscious dogs before CPB and again in the same animals 3-4 days post-CPB. The dose of U-46619 used to acutely preconstrict the pulmonary circulation to similar levels pre- and post-CPB was decreased (0.13 +/- 0.01 vs. 0.10 +/- 0.01 mg.kg-1.min-1, P < 0.01) after CPB. Acetylcholine, bradykinin, and sodium nitroprusside all caused dose-dependent pulmonary vasodilation pre-CPB. The pulmonary vasodilator response to acetylcholine was completely abolished post-CPB. For example, at left pulmonary blood flow of 80 ml.kg-1.min-1 acetylcholine (10 micrograms.kg-1.min-1) resulted in 72 +/- 15% reversal (P < 0.01) of U-46619 preconstriction pre-CPB but caused no change post-CPB. However, the responses to bradykinin and sodium nitroprusside ...Continue Reading

References

Aug 1, 1992·Journal of Applied Physiology·P A MurrayD P Nyhan
Feb 1, 1992·Journal of Applied Physiology·D P NyhanP A Murray
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P KubesD N Granger
Nov 1, 1991·Journal of Applied Physiology·H A el-KashefJ D Catravas
Dec 1, 1990·Journal of Applied Physiology·W K Adkins, A E Taylor
Feb 1, 1990·The Journal of Clinical Investigation·C Boulanger, T F Lüscher
Jul 1, 1987·Journal of Applied Physiology·D P NyhanP A Murray
May 1, 1988·Journal of Applied Physiology·A L Hyman, P J Kadowitz
Oct 1, 1994·Journal of Applied Physiology·D P NyhanP A Murray
May 1, 1993·Journal of Vascular Research·K L DavenpeckA M Lefer
Jun 1, 1996·The Journal of Thoracic and Cardiovascular Surgery·P M KirshbomJ W Gaynor
Apr 1, 1988·Journal of Cardiothoracic Anesthesia·D K CopeA E Taylor

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