PMID: 6171028Jan 1, 1981Paper

Selective enhancement of human mononuclear leucocyte cytotoxic function by interferon

Scandinavian Journal of Immunology
I Kimber, M Moore

Abstract

The influence of type I interferon (IFN) on leucocyte-mediated antibody-dependent cellular cytotoxicity (ADCC) has been examined in a system in which differential alloantibody sensitization of human erythrocyte target cells allows discrimination between lymphocyte and monocyte effector function. ADCC mediated by unfractionated mononuclear leucocyte populations was regularly enhanced by interferon pretreatment over a range of concentrations of the sensitizing antibody. The capacity of IFN-augmented reactivity was, however, removed with adherent cell depletion, suggesting that lymphocyte (K-cell) effectors are not modulated by IFN, even though such populations demonstrate IFN-potentiated natural killer (NK) reactivity against K562. These results suggest that monocyte and NK cell function but not K-cell activity was influenced by interferon.

References

Jan 1, 1979·International Archives of Allergy and Applied Immunology·A M Attallah, T Folks
Jan 1, 1978·Cellular Immunology·R M SchultzU I Heine
Apr 1, 1976·Infection and Immunity·R M Donahoe, K Y Huang
Jan 1, 1972·International Archives of Allergy and Applied Immunology·G Holm
Nov 1, 1971·Infection and Immunity·K Y HuangH R Dressler
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg
Mar 1, 1971·American Journal of Clinical Pathology·L T YamW H Crosby
Mar 1, 1980·British Journal of Cancer·M Moore, M R Potter

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Citations

Jan 1, 1986·International Archives of Occupational and Environmental Health·I KimberZ Niewola
Jan 1, 1986·International Journal of Immunopharmacology·S E ChristmasM Moore
Jan 1, 1983·Journal of Interferon Research·K G McCullaghM Houghton
Mar 1, 1983·The American Journal of Medicine·R P Kimberly, P Ralph

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