Selective Essential Oils from Spice or Culinary Herbs Have High Activity against Stationary Phase and Biofilm Borrelia burgdorferi

Frontiers in Medicine
Jie FengYing Zhang

Abstract

Although the majority of patients with acute Lyme disease can be cured with the standard 2-4 week antibiotic treatment, about 10-20% of patients continue suffering from chronic symptoms described as posttreatment Lyme disease syndrome. While the cause for this is debated, one possibility is that persister bacteria are not killed by the current Lyme antibiotics and remain active in the system. It has been reported that essential oils have antimicrobial activities and some have been used by patients with persisting Lyme disease symptoms. However, the activity of essential oils against the causative agent Borrelia burgdorferi (B. burgdorferi) has not been well studied. Here, we evaluated the activity of 34 essential oils against B. burgdorferi stationary phase culture as a model for persister bacteria. We found that not all essential oils had activity against the B. burgdorferi stationary phase culture, with top five essential oils (oregano, cinnamon bark, clove bud, citronella, and wintergreen) at a low concentration of 0.25% showing high anti-persister activity that is more active than the known persister drug daptomycin. Interestingly, some highly active essential oils were found to have excellent anti-biofilm ability as shown ...Continue Reading

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Citations

Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nagaraj BasavegowdaKwang-Hyun Baek
Feb 6, 2019·BMC Complementary and Alternative Medicine·Anna GocMatthias Rath
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Jan 30, 2021·Microbial Cell Factories·Dana VigasovaJiri Damborsky
Oct 20, 2018·Journal of Proteome Research·Jordy Evan SulaimanHenry Lam

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Methods Mentioned

BETA
Assay
fluorescence microscopy

Software Mentioned

- X Analyzer
Image Pro - Plus
BZ

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